Main description:

Written by a leading international authority in the field, this book is ideal for physicians and residents in nuclear medicine who want to improve their knowledge in internal dosimetry. The text is a practical introduction that guides the reader through fundamental concepts in the calculation of radiation dose, including discussions of standardized models, methods of calculations, and available software applications. This comprehensive guide discusses too the biological effects of radiation on living systems. The book also includes an overview of regulatory aspects related to the radiation dosimetry of new radiopharmaceuticals.

Contents:

Uses of Dosimetry Information in Nuclear Medicine.- Diagnostic vs. Therapeutic Applications.- Model-Based vs. Patient-Based Approaches.- Practical Dosimetry: Balancing Benefits and Risks.- Clinical Utility: Interface of pPtient, Physician, and Physicist. Fundamental Concepts: Calculating Radiation Dose.- Dosimetry Quantities and Units.- Dosimetry Systems. Models and Resources for Internal Dose Calculations.- Standardized Models for Dosimetry.- Input Data for Dose Calculations.- Standard Dose Estimates for Radiopharmaceuticals.- Modifications to the Standard Models.- The Pregnant Patient.- The Breastfeeding Patient. Steps in Dose Calculations.- Choice and Application of Standardized Models.- Internal Dose Calculations.- Image Quantification: Human Data.- Kinetic Analysis.- Dose Calculations.- Teaching Examples.- Image-Based, Patient-Individualized Dosimetry. Case Studies.- Development of New Diagnostic Radiopharmaceuticals.- Development of Radiopharmaceuticals for Therapy.- The Pregnant Patient. Biological Effects of Radiation.- Basic Principles.- Mechanisms of Radiation Damage to Biological Systems.- Observed Biological Effects in Humans.- Cancer.- Cell Survival Studies.- Related Biological Effectiveness.- New Evidence: and Some Confusion!.- Use of Radiation Dosimetry in Patient Therapy Treatment Planning. Regulatory Aspects of Dose Calculations.- The Philosophy of Radiation Protection.- Scientific Advisory Bodies.- Regulatory Bodies.