Main description:

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.

Contents:

G Protein-coupled receptors in energy homeostasis and obesity: An introduction

Y. Tao

Ghrelin receptor in energy homeostasis and obesity pathogenesis

W. Zhang

Obestatin receptor in energy homeostasis and obesity pathogenesis

J. Zhang

Melanocortin-3 receptor in energy homeostasis and obesity pathogenesis

A. Butler

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis

A. Hinney

G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis

H. Shi

Relaxin-3 receptor in energy homeostasis and obesity pathogenesis

C. Liu

Cholecystokinin receptor in energy homeostasis and obesity pathogenesis

A. Sayegh

Adiponectin receptor in energy homeostasis and obesity pathogenesis.

B. Akingbemi