Main description:

The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care.
This text focuses on clinical utility and validity and serves as an "owner's manual" in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.

Contents:

PREFACE

Laura J. Tafe, MD and Maria E. Arcila, MD

PART I: GENERAL CONCEPTS

Chapter 1: Pre-Analytics, Current Testing Technologies, and Limitations of Testing

Alejandro Luina Contreras, MD; Jose Jasper C. Andal, MD; Raymundo Lo, MD; Daphne Chua Ang, MD

Chapter 2: Next Generation Sequencing

Alanna J. Church, M.Sc., M.D.

Chapter 3: Cell Free DNA Testing

Brennan Decker, MD, PhD and Lynette M. Sholl, MD

Chapter 4: Role of Bioinformatics in Molecular Medicine

Chad Vanderbilt, M.D., Sumit Middha, Ph.D.

Chapter 5: Interpreting Genomic Reports

Alejandro Luina Contreras, M.D.

PART II: APPLICATIONS IN SOLID TUMORS

Chapter 6: Lung Carcinoma

Maria E Arcila, Jason C Chang, Laura J Tafe

Chapter 7: GI including GIST

Efsevia Vakiani, MD, PhD

Chapter 8: Breast

Dara S. Ross, MD

Chapter 9: Genitourinary Tumors

Marie-Lisa Eich and George J. Netto

Chapter 10: Gynecologic Malignancies

Jessica L. Dillon, MD and Laura J. Tafe, MD

Chapter 11: Sarcomas

Konstantinos Linos MD, FCAP, FASDP

Chapter 12: Salivary Gland Carcinomas

Snjezana Dogan, MD

Chapter 13: Sinonasal Carcinomas

Snjezana Dogan, MD

PART III: APPLICATIONS IN HEMATOPATHOLOGY

Chapter 14: Acute Myeloid Neoplasms

Eric Y. Loo, MD

Chapter 15: Chronic Myeloid Neoplasms

Maria E. Arcila and Caleb Ho

Chapter 16: Lymphomas

Vignesh Shanmugam, MD and Annette S. Kim, MD, PhD