Main description:

This book evaluates trends arising in "-Omics" sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology.

Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.

Contents:

Chapter 1. Rethinking drug discovery and targeting after the genomic revolution

Dharmesh R Chejara, Ravindra V Badhe, Pradeep Kumar, Yahya E Choonara, Lomas K Tomar, Charu Tyagi, Viness Pillay

Chapter 2. Living between sickness and health: Where is the human genome leading us?

Amy Broadwater, Yashwant Pathak

Chapter 3. Pharmacogenomics: Setting Newer Paradigms of Genetics in Therapy and Medicine

Sanjay Dey, Kumud Joshi, Bhaskar Mazumder

Chapter 4. Bioinformatics and Pharmacogenomics: Tools to Understand and Accelerate Infectious Disease Control

Ashwani sharma, Subrata Sinha, Surabhi Johari, Bhaskar Mazumder

Chapter 5. Race and Ethnicity - Understanding Difference in the Genome Era

Shannon Kelly, Yashwant Pathak

Chapter 6. The Food Metabolome and Novel Dietary Biomarkers Associated with Diseases

Orhan E Arslan, Philip Palmon

Chapter 7. Impact of genomics on drug discovery and clinical medicine

Deepak Gupta

Chapter 8. Genomics and drug transporters and application in drug discovery, delivery and development

Robert Gharavi, Hazem E. Hassan

Chapter 9. Genomics and drug metabolizing enzymes its application in Drug delivery: Evaluating the influence of the microbiome

Sheeba Varghese Gupta

Chapter 10. Essentials of Genomics in the Continuum of Translational Research

Sadaf Aslam

Chapter 11. Charting a course for genomic medicine from base pair to bedside

Teresa Vo

Chapter 12. Pharmacogenomics and pharmacoepigenomics: impact on therapeutic strategies

Kristopher R Hall, Tamer E. Fandy

Chapter 13. Clinical Pharmacogenomics and Personalized Medicine: New strategies to maximize drug efficacy and avoid adverse drug reaction

Chonlaphat Sukasem, Sadeep Medhasi

Chapter 14. Epigenetic Patterns/Therapies associated with Genetic Disorders

Mazzio Elizabeth, Soliman KFA

Chapter 15. Neurodegenerative disease conditions and genomic treatment for better health

Ravindra V. Badhe, Dharmesh R. Chejara, Pradeep Kumar, Yahya E. Choonara, Viness Pillay

Chapter 16. Recent Trends in -Omics based methods and techniques for Lung Diseases prevention

Raisah Salhab, Yashwant V Pathak

Chapter 17. Impact of Genomics on Personalization of Breast Cancer Care

F. Scott Heinemann, Alice Police, Erin Lin, Mandy Liu, Sherry Liang, Ying Huang

Chapter 18. Pharmacogenomics: a new approach for preventing severe cutaneous adverse drug reactions

Chonlaphat Sukasem, Therdpong Tempark