Main description:

The best edition yet of the landmark text in medical toxicology
Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins.
Fully referenced and supported by a cohesive organization and full-color format, Goldfrank's begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations.
The Eleventh Edition of Goldfrank's Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis.
New to this Edition: *Additional cases and "Special Considerations" chapters designed to enhance clinical decision-making and patient outcomes*New "Antidotes in Depth" provides timely, critical information on toxicologic treatment strategies *New content on toxicogenomics explores its increasingly important role in predictive toxicology*Chapter-ending bulleted summaries of key points *Updated coverage of synthetics such as "K2" *Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools

Contents:

1. Historical Principles and Perspectives

Paul M. Wax

2. Toxicologic Misfortunes and Catastrophes in History

Paul M. Wax

PART A

THE GENERAL APPROACH TO THE PATIENT

3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes

Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman

4. Principles of Managing the Acutely Poisoned or Overdosed Patient

Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions]

SC1. Principles of Antidote Stocking

[Insert author(s)]

5. Decontamination Principles: Prevention of Gastrointestinal Absorption

Lotte C. G. Hoegberg and Anne-Bolette Gude

SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption

[Insert author(s)]

A1. Activated Charcoal

Silas W. Smith and Mary Ann Howland

A2. Whole-Bowel Irrigation and Other Intestinal Evacuants

Silas W. Smith and Mary Ann Howland

6. Principles and Techniques Applied to Enhance Elimination

David S. Goldfarb and Marc Ghannoum

7. Laboratory Principles

Petrie M. Rainey

8. Principles of Diagnostic Imaging

David T. Schwartz

9. Pharmacokinetic and Toxicokinetic Principles

Mary Ann Howland

PART B

THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY

SECTION I

BIOCHEMICAL AND MOLECULAR CONCEPTS

10. Chemical Principles

Stephen J. Traub and Lewis S. Nelson

11. Biochemical and Metabolic Principles

Kurt C. Kleinschmidt and Kathleen A. Delaney

12. Fluid, Electrolyte, and Acid-Base Principles

Alan N. Charney and Robert S. Hoffman

13. Neurotransmitters and Neuromodulators

Steven C. Curry, Ayrn D. O'Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik

14. Withdrawal Principles

Richard J. Hamilton and [new author]

SECTION II

PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS

15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles

Cathleen Clancy

16. Cardiologic Principles II: Hemodynamics

[new author] and Robert A. Hessler

17. Dermatologic Principles

Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson

SC3. Transdermal Toxicology

Lewis S. Nelson

18. Gastrointestinal Principles

Matthew D. Zuckerman and Richard J. Church

19. Genitourinary Principles

Jason Chu

20. Hematologic Principles

Marco L.A. Sivilotti

21. Hepatic Principles

Kathleen A. Delaney

22. Neurologic Principles

Rama B. Rao

23. Oncologic Principles

Richard Wang

24. Ophthalmic Principles

Adhi Sharma

25. Otolaryngologic Principles

[new author] and William Chiang

26. Psychiatric Principles

Erin A. Zerbo and Andrea M. Kondracke