Main description:

The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light.

Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain.

Key Features:

Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels.
Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice.
Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging.
Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Contents:

Contents

Preface, ix

Contributors, xi

Part I Function and Structural Neurophotonic Imaging

Chapter 1 ? Miniaturized Optical Neuroimaging Systems 3

Hang Yu, Janaka Senarathna, Betty M. Tyler, Nitis h V. Thakor, and Arvi nd P. Pathak

Chapter 2 ? Functional Imaging with Light-Sheet Microscopy 21

Raghav K. Chhetri and Philipp J. Keller

Chapter 3 ? Two-Photon Microscopy in the Mammalian Brain 55

Hod Dana and Shy Shoham

Chapter 4 ? Light Field Microscopy for In Vivo Ca2+ Imaging 81

Tobi as Noebauer and Alip asha Vaziri

Chapter 5 ? Genetically Encoded Activity Indicators 113

Chenchen Song and Thomas Knoepfel

Chapter 6 ? Functional Optoacoustic Imaging 129

Daniel Razansky

Chapter 7 ? Imaging Deep in the Brain with Wavefront Engineering 147

Roarke Horstmeyer, Maximi llian Hoffmann, Haowen Ruan, Benjami n Judkewitz,

and Changhuei Yang

Chapter 8 ? Nanoscopic Imaging to Understand Synaptic Function 173

Daniel Choquet and Anne-Sophie Hafner

Chapter 9 ? Chemical Clearing of Brains 191

Klaus Becker, Chris tian Hahn, Nina Jahrling, Marko Pende,

Inna Sabdyusheva-Litsc hauer, Saiedeh Saghafi, Martina Wanis , and Hans-Ulric h Dodt

Chapter 10 ? Advanced Light-Sheet Microscopy to Explore Brain

Structure on an Organ-Wide Scale 221

Ludovic o Silvestri and Francesc o S. Pavone

Part II Neurophotonic Control and Perturbation

Chapter 11 ? Optogenetic Modulation of Neural Circuits 235

Mathias Mahn, Oded Klavi r, and Ofer Yizhar

Chapter 12 ? Molecular Photoswitches for Synthetic Optogenetics 271

Shai Berlin and Ehud Y. Isacoff

Chapter 13 ? Applications of Nanoparticles for Optical Modulation of

Neuronal Behavior 293

Chiara Pavi olo, Shaun Gietman, Daniela Duc, Sim on E. Moulton, and

Paul R. Stoddart

Chapter 14 ? Optical Stimulation of Neural Circuits in Freely Moving

Animals 317

Leore R. Heim and Eran Stark

Chapter 15 ? Holographic Optical Neural Interfaces (HONIs) 333

Shani Rosen, Shir Paluch, and Shy Shoham

Chapter 16 ? Multi-Photon Nanosurgery 353

Anna Letizia Allegra Masc aro and Francesc o Saverio Pavone

Part III Clinical and Human Neurophotonics

Chapter 17 ? High Resolution Diffuse Optical Tomography of the

Human Brain 369

Muriah D. Wheelock and Adam T. Eggebrecht

Chapter 18 ? Human Brain Imaging by Optical Coherence Tomography 399

Caroline Magnain, Jean C. Augustinack, Davi d Boas, Bruce Fisc hl, Taner Akkin,

Ender Konukoglu, and Hui Wang

Chapter 19 ? Acousto-Optic Cerebral Monitoring 439

Mic hal Balberg and Revi tal Pery-Shechter

Chapter 20 ? Neurophotonic Vision Restoration 459

Adi Schejter Bar-Noam and Shy Shoham

Chapter 21 ? Optical Cochlear Implants 473

C.-P. Ric hter, Y. Xu, X. Tan, N. Xia, and N. Suematsu

Chapter 22 ? Label-Free Fluorescence Interrogation of Brain Tumors 503

Brad A. Hartl, Shami ra Sridharan, and Laura Marcu

Chapter 23 ? Higher Harmonic Generation Imaging for Neuropathology 527

Nikolay Kuzmi n, Sander Idema, Eleonora Aronic a, Philip C. de Witt Hamer,

Pieter Wess eling, and Marie Louis e Groot

INDEX, 545