Main description:

Hayes' Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field.

Key Features:

The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.

Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.

All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences

New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary.

The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology").

This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Contents:

SECTION I Principles of Toxicology. 1.History, Understanding and a Possible Future of Toxicology. Harming and Helping through time. 2.Use of Toxicology in the Regulatory Process. 3.The Dose-Response: A Fundamental Concept in Toxicology. 4.Metabolism: A Determinant of Toxicity. 5.Toxicokinetics. 6.Physiologically Based Pharmacokinetic and Toxicokinetic Models 7.Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, Metabolomics and Lipidomics in Predictive Mechanistic Toxicology. 8.Toxicologic Assessment of Pharmaceutical, Medical Device and Biotechnology Products. 9. Statistics and Experimental Design for Toxicologists.10.The Practice of Exposure Assessment. 11.Epidemiology for Toxicologists. 12.Pathology Principles and Practices for Toxicity Studies.13.Chemical Toxicology Information Resources. SECTION II Agents. 14.Food Safety and Foodborne Toxicants. 15.Plant and Animal Toxins. 16.Safety Assessment of Cosmetics and Personal Care Products. 17. Solvents and Industrial Hygiene. 18.Crop Protection Chemicals: Mechanism of Action and Hazard Profiles. 19.Metals. 20.Radiation Toxicity. SECTION III Methods. 21.The Humane Care and Use of Laboratory Animals in Toxicology Research.22. Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies.23.Modern Instrumental Methods for Studying Mechanisms of Toxicology. 24.Acute Toxicity and Eye Irritancy. 25. Short-Term, Subchronic, and Chronic Toxicology Studies. 26.Genetic and Epigenetic Toxicology. 27.Carcinogenicity Bioassays and Related Assays; Human Relevance. 28.Assessment of Behavioral Toxicity. SECTION IV Organ- and System-Specific Toxicology. 29.Dermatotoxicology. 30.Inhalation Toxicology. 31.Gastrointestinal Toxicology. 32. Hepatotoxicology. 33.Principles and Methods for Renal Toxicology. 34.Cardiovascular Toxicology Methods. 35.Neurotoxicology.36.Toxicology of the Endocrine System. 37.Assessment of Male Reproductive Toxicity. 38.Female Reproductive and Developmental Toxicology. 39.Immunotoxicology. The Immune System Response to Toxic Insult.