Contents:

1. Introduction - a brief history of Hh

2. The Hh signaling pathway in Drosophila

3. The evolution of the Hh pathway

4. Production distribution and reception of the HH ligand

5. The Primary Cilium in HH signalling

6. Mechanisms of Hh signaling in mouse

7. Mechanisms of Hh signaling in zebrafish

8. Hh signaling in neural tube patterning in vertebrates

9. Hh signaling in limb development

10. Hh signaling in endodermal organs

11. Hh signaling in myogenesis

12. Hh signaling in skin biology

13. Hh signaling in bone biology

14. Hh signaling in blood and vascular biology

15. Physiological roles of HH

16. Hh signaling in regeneration

17. Hh and human congenital disorders

18. Hh in regenerative medicine

19. Hh in tumorigenesis 1

20. Hh in tumorigenesis 2

21. Hh in tumorigenesis 3

22. Hh therapeutics

Authors:

P Ingham (IMCB, Singapore)

M Scott (Stanford)

P Beachy (Stanford)

P Therond (CNRS, Nice)

A McMahon (Harvard/USC)

J Briscoe (Mill Hill)

M. Placzek (U Sheffield)

C. Tabin (Harvard Med School)

C. Tickle (U Bath)

D. Gummucio (U Michigan)

A-G Borycki (U Sheffield)

A Vortkamp (U Duisberg-Essen)

S Eaton (MPI Dresden)

K Anderson (MSK)

J Reiter (UCSF)

R Toftgard (Karolinska)

N Lawson (U Mass)

T Crompton (ICH, London)

P. Beales (ICH, London)

Y Sasai (Riken, Kobe)

T Curran (U Penn)

A Oro (Stanford)

F de Sauvage (Genentech, San Francisco)