Main description:

In this book and atlas entitled High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease, I am indebted to the many chapter authors who have contributed their writing as well as their insights. The work grew out of a meeting on high density lipoproteins (HDLs), chaired by me and Dr. Vassilis Zannis of Boston University, and held on June 19 and 20, 2009 in Newport, Rhode Island, as a satellite meeting following the 15th International Symposium on Atherosclerosis, held in Boston. In the introduction our understanding of overall lipoprotein metabolism is reviewed, as well as the common genetic lipoprotein disorders associated with premature coronary heart disease (CHD). These familial disorders include lipoprotein(a) excess, dyslipidemia (high triglycerides and low HDL), combined hyperlipidemia (high cholesterol and high triglycerides often with low HDL), hypoalphalipoproteinemia (low HDL), and hyperc- lesterolemia. We discuss the management of these disorders. We also review other disorders including cerebrotendinous xanthomatosis, phytosterolemia, defciency of apolipoprotein B, and severe hypertriglyceridemia. The latter disorder can be associated with pancreatitus.
Thereafter, the focus is on HDL, beginning with chapters on the regulation of apolipop- tein (apo) A-I gene expression, the composition, remodeling, and the metabolism of HDL particles, as well as HDL structure, function, and its anti-infammatory properties.

Contents:

1. Introduction to HDL, Dyslipidemia, and Coronary Heart Disease2. Regulation of Apolipoprotein A-I Gene Expression, Synthesis, and Function3. The Many and Varied Functions of HDL4. HDL Particle Composition, Proteomics, and Metabolism5. HDL Structure, Function, and Anti-inflammatory Properties6. Human ApoA-I Deficiency7. Human ApoA-I Variants8. Cellular Cholesterol Efflux 1: ABCA 1 Function and Deficiency9. Cellular Cholesterol Efflux 2: ABCG1 Function10. Cellular Cholesterol Efflux 3: ABCA1, ABCG1 and HDL Particle Interaction11. Cholesterol Esterification and Human LCAT Deficiency12. Effects of Lipoprotein Lipase and Hepatic Lipase Deficiency on HDL Metabolism13. Cholesteryl Ester Transfer Protein (CEPT) and Human CETP Deficiency14. HDL Metabolism and Scavenger Receptor B115. The Genetics of HDL16. Effects of Nutrition and Excersize on HDL Metabolism17. Effects of Alcohol on HDL Metabolism18. Effects of Estrogens on HDL Metabolism19. Efects of Niacin on HDL Metabolism20. Effects of Statins on HDL Metabolism21. Effects of Fibrates on HDL Metabolism22. Effects of Cholesterol Ester Transfer Protein Inhibition on HDL Metabolism23. Oral and HDL Infusion Therapy to Enhance Reverse Cholesterol Transport24. Conclusions