Main description:

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.

Contents:

Table of Contents

High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management

Chrysalyne D. Schmults, editor

Dedication

Preface

Part I. Defining the Problem of High-risk SCC

Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma

Pritesh S. Karia

Tumor Staging Systems and Prognostic Stratification

Anokhi Jambusaria-Pahlajani

Part II. The Science of SCC

Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-risk Cutaneous Squamous Cell Carcinoma

Catherine Anne Harwood, Charlotte Proby, Sarah Arron

Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications

Valerie Yanofsky, John A. Carucci, Gunther F.L. Hofbauer

Part III. Management of High-risk SCC

Management of Patients with Multiple SCCs/Field Cancerization

Sasha Jenkins Haberle, Lauren Rimoin, Myrto Georgia Trakatelli, Fiona Zwald

Management of High-Risk Primary Tumors including Nodal Staging

Vishal Anil Patel, Christian L. Baum, Desiree Ratner

Management of Local Recurrence and In-transit Metastasis

Vitaly Terushkin, John A. Carucci

Management of Nodal Metastases

Michael Veness, Julie Howle

Management of Widely Metastatic and Unresectable Cutaneous Squamous Cell Carcinoma

Glenn J. Hanna, Emily Stamell Ruiz, Jochen H. Lorch

Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Management

Travis W. Blalock, Thomas Stasko