Main description:

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

Contents:

SECTION I: HSP70 in Neuro-OnCOlogical Disorders

Chapter 1. Heat Shock Protein 70 and Molecular Confession during Neurodegeneration

Komal Panchal, Ajay Kumar and Anand K. Tiwari

Genetics & Developmental Biology Laboratory

Indian Institute of Advanced Research/IAR

Gandhinagar, India

Chapter 2. Hsp70-Family Proteins and Neurodegenerative Diseases

Zheying Sun, Roy J. Blackburn, Laura J. Blair and John Koren III

Department of Molecular Medicine

University of South Florida

Tampa, FL

Chapter 3. Heat Shock Protein70 in Neurological Disease

Pinar Ortan, Ozden Yildirim Akan and Ferda Hosgorler

Division of Neurology

SB University Izmir Bozyaka Training and Research Hospital

Alsancak Izmir, Turkey

Chapter 4. Involvement of Heat Shock Protein 70 (Hsp70) in Gastrointestinal Cancers

Dipamoy Datta, Suparna Banerjee, Anupama Ghosh, Soumyajit Banerjee Mustafi, Prosenjit Sen and Sanghamitra Raha

Department of Biotechnology

Visva-Bharati

Santiniketan, India

Chapter 5. Heat Shock Protein 70 and Cancer

Tuoen Liu and Shousong Cao

Department of Biomedical Sciences

West Virginia School of Osteopathic Medicine

Lewisburg, USA

Chapter 6. Implication of HSP70 in the Pathogenesis of Gastric Cancer

Prakash Chand Sharma and Renu Verma

University School of Biotechnology

Guru Gobind Singh Indraprastha University

New Delhi, India

SECTION II: HSP70 IN Circulatory Disorders

Chapter 7. Double Face of eHsp70 in Front of Different Situations

Maria M. Barreca and Fabiana Geraci

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies

University of Palermo and Euro-Mediterranean Institute of Science and Technology

Palermo, Italy

Chapter 8. HSP70 is a Major Contributor to the MHCII Ligandome and Inducer of Regulatory T Cells

Willem van Eden, Femke Broere and Ruurd van der Zee

Division of Immunology

Utrecht University

Utrecht, The Netherlands

Chapter 9. Immune Properties of HSP70

Yves Delneste, Vincent Larochette and Pascale Jeannin

Universite d'Angers and LabEx ImmunoGraftOnco and Laboratory of Immunology and Allergology, University Hospital of Angers

Angers, France

Chapter 10. Molecular Chaperones Regulating the Dynamics, Composition and Functionality of RNP Granules: Implications for Age-related Diseases

Daniel Mateju, Laura Mediani, Federica F. Morelli, Simon Alberti and Serena Carra

Department of Biomedical, Metabolic and Neural Sciences

University of Modena and Reggio Emilia

Modena, Italy

Chapter 11. Heat Shock Proteins in Cardiovascular Diseases: From Bench to Bedside

Francesca Bonomini, Gaia Favero, Valentina Trapletti and Rita Rezzani

Department of Clinical and Experimental Sciences

University of Brescia

University of Brescia, Italy

Chapter 12. Clinical Implication of Heat Shock Protein 70 in Kidney Disease

Alev Yilmaz and Zeynep Nagehan Yuruk Yildirim

Istanbul University Istanbul Faculty of Medicine

Pediatric Nephrology Department

Istanbul, Turkey

Chapter 13. Heat Shock Proteins in the Kidney - What is Known About their Role in Kidney Disease

Shobhana Nayak Rao

Department of Nephrology

K.S. Hegde Medical Academy Medical Sciences Complex

Derlakatte, India

Chapter 14. Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina

Ting Zhang, Bobak Bahrami and Ling Zhu

Save Sight Institute

The University of Sydney

Sydney, Australia

SECTION III: HSP70 as a Therapeutic target

Chapter 15. Emerging Role of HSP70 in Human Diseases

Anjali Garg, Bandana Kumari and Manish Kumar

Department of Biophysics

University of Delhi South Campus

New Delhi, India

Chapter 16. Intranasal Administration of Hsp70: Molecular and Therapeutic Consequences

Evgen'ev Michail, Garbuz David, Morozov Alexey and Bobkova Natalia

Engelhardt Institute of Molecular Biology

Institute of Cell Biophysics

Pushchino, Russia

Chapter 17. The Effectiveness of Antitumor Vaccine Enriched with a Heat Shock Protein 70

Gennadiy Didenko, Olena Kruts, Larysa Skivka and Yuriy Prylutskyy

Taras Shevchenko National University of Kyiv

Kyiv, Ukraine

Chapter 18. Mammalian Heat Shock Protein Hsp105: The Hsp70 Inducer and a Potent Target for Cancer Therapy

Youhei Saito and Yuji Nakayama

Department of Biochemistry and Molecular Biology

Kyoto Pharmaceutical University

Kyoto, Japan

Chapter 19. Suppression of HSP70 Expression by Quercetin and its Therapeutic Potential against Cancer

Evren OEnay Ucar, Aslihan Sengelen, Elif Mertoglu, Murat Pekmez and Nazli Arda

Department of Molecular Biology & Genetics, Faculty of Science, Istanbul University, Istanbul, Turkey.

Chapter 20. Hsp70 in Fungi: Evolution, Function and Vaccine Candidate

Shraddha Tiwari and Jata Shankar

Department of Biotechnology and Bioinformatics

Jaypee University of Information Technology

Solan, India