Main description:

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Contents:

Mechanisms underlying metastatic pancreatic cancer.- Current Perspectives on Nasopharyngeal Carcinoma.- An in Vitro Model of Triple Negative Breast cancer.- Emerging role of novel biomarkers of Ly6 gene family in pan cancer.- The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy.- Contributing roles of CYP2E1 and other cytochrome P450 isoforms in alcohol-related carcinogenesis.- Novel Human Prostate Epithelial Cell Cultures.- African American Prostate Normal and Cancer Cells for Health Disparities Research.- Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-Clinical Model for Prostate Cancer Research.- Role of alternative splicing in prostate cancer aggressiveness and drug resistance in African Americans.- Research Article: Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients.- The Aging Skeleton.- Parathyroid Hormone Related Protein (PTHrP): an Emerging Target in Cancer Progression and Metastasis.- Targeting DNA hypomethylation in malignancy by epigenetic therapies.- Tumor Dormancy and Slow-Cycling Cancer Cells.- Resolution of Cellular Heterogeneity in Human Prostate Cancers: Implications for Diagnosis and Treatment.- Small molecule inhibition of glycogen synthase-kinase 3 in cancer immunotherapy.