Main description:

This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled "Immunology for Epidemiologists" at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.

Contents:

Section I. Introduction Chapter 1. Introduction to Immunology, Epidemiology, and Immunoepidemiology

Linda Niccolai, Nancy H. Ruddle, and Peter J. Krause

Chapter 2. Organization and Cells of the Immune System

Paula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhD

Chapter 3. Innate Immunity: Recognition and Effector Functions

Paula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhD

Chapter 4. Adaptive Immunity: Antigen Recognition by T and B Lymphocytes

Paula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhD

Chapter 5 Adaptive Immunity: Effector Functions, Regulation, and Vaccination

Paula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhD

Chapter 6. Disorders of the Immune System

Paula B. Kavathas, PhD, Peter J. Krause, MD, Nancy H. Ruddle, PhD

Chapter 7. Polymorphisms of Selected Components of the Innate and Adaptive Immune Systems

Nancy H. Ruddle and Paula B. Kavathas

Chapter 8. Immunoepidemiology of Immune Dysfunction

Eric Meffre, Peter J. Krause and Nancy H. Ruddle

Chapter 9. Immunoepidemiology of Mycobacterium tuberculosis

Camila D. Odio, Richard J. Bucala

Chapter 10. Host Immunity to Human immunodeficiency Virus Infection

Elijah Paintsil

Chapter 11. Fungal Immunoepidemiology

Marwan M. Azar

Chapter 12. Immunoepidemiology of Plasmodium falciparum Malaria

Amy K. Bei, Sunil Parikh

Chapter 13. Immunoepidemiology of Cancer

Xiaomei Ma, Rong Wang

Chapter 14. Modeling Approaches Toward Understanding Infectious Disease Transmission

Laura A. Skrip, Jeffrey P. Townsend

Chapter 15. Vaccines

Diane McMahon-Pratt

Chapter 16. Immunotherapy for Infectious Diseases, Cancer, and Autoimmunity

Peter J. Krause, Paula B. Kavathas, Nancy H. Ruddle

Appendix

Jane O'Bryan, Kara Fikrig, Peter J. Krause, Kate Nyhan