Main description:

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab.
Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Contents:

1. Reverse Vaccinology and Its Applications

Amol M. Kanampalliwar

2. Computational Methodology for Peptide Vaccine Design for Zika Virus: A Bioinformatics Approach

Ashesh Nandy, Smarajit Manna, and Subhas C. Basak

3. High-Definition Genomic Analysis of HLA Genes via Comprehensive HLA Allele Genotyping

Shuji Kawaguchi and Fumihiko Matsuda

4. A Computational Vaccine Designing Approached for MERS-CoV Infections

Hiba Siddig Ibrahim and Shamsoun Khamis Kafi

5. n Alignment-Independent Platform for Allergenicity Prediction

Ivan Dimitrov and Irini Doytchinova

6. Immunoinformatics and Epitope Prediction

Jayashree Ramana and Kusum Mehla

7. Vaccine Design against Leptospirosis Using an Immunoinformatics Approach

Kumari Snehkant Lata, Vibhisha Vaghasia, Shivarudrappa Bhairappanvar, Saumya Patel, and Jayashankar Das

8. Characterizing MHC-I Genotype Predictive Power for Oncogenic Mutation Probability in Cancer Patients

Lainie Beauchemin, Michael Slifker, David Rossell, and Joan Font-Burgada

9. Network Analysis of Large-Scale Data and Its Application to Immunology

Lauren Benoodt and Juilee Thakar

10. In Silico Guided Sequence Modification of Epitopes in Cancer Vaccine Development

Winfrey Pui Yee Hoo, Pui Yan Siak, and Lionel L.A. In

11. An Immunoinformatics Approach in Design of Synthetic Peptide Vaccine Against Influenza Virus

Neha Lohia and Manoj Baranwal

12. A New Approach to Assess mAb Aggregation

Illarion V. Turko

13. Generation of Variability-Free Reference Proteomes from Pathogenic Organisms for Epitope-Vaccine Design

Jose L. Sanchez-Trincado and Pedro A. Reche

14. Immunoinformatic Identification of Potential Epitopes

Priti Desai, Divya Tarwadi, Bhargav Pandya, and BhruguYagnik

15. Immunoinformatic Approaches for Vaccine Designing Against Viral Infections

Richa Anand and Richa Raghuwanshi

16. EPCES and EPSVR: Prediction of B-Cell Antigenic Epitopes on Protein Surfaces with Conformational Information

Shide Liang, Dandan Zheng, Bo Yao, and Chi Zhang

17. SVMTriP: A Method to Predict B-Cell Linear Antigenic Epitopes

Bo Yao, Dandan Zheng, Shide Liang, and Chi Zhang

18. Modeling Phage-Bacteria Dynamics

Saptarshi Sinha, Rajdeep Kaur Grewal, and Soumen Roy

19. Dynamics of Mycobacteriophage -Mycobacterial Host Interaction

Arabinda Ghosh, Tridip Phukan, Surabhi Johari, Ashwani Sharma, Abha Vashista, and Subrata Sinha

20. Multiplexing of Immune Markers via Electrochemiluminescence Immunoassays for Systems Biology

Vrushali Abhyankar and Ammaar H. Abidi

21. AAgAtlas 1.0: A Database of Human Autoantigens Extracted from Biomedical Literature

Dan Wang, Yupeng Zhang, Qing Meng, and Xiaobo Yu

22. Application of Meta Learning to B-Cell Conformational Epitope Prediction

Yuh-Jyh Hu

23. PCPS: A Web Server to Predict Proteasomal Cleavage Sites

Marta Gomez-Perosanz, Alvaro Ras-Carmona, and Pedro A. Reche