Main description:

Leading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.

Contents:

Basic Mechanisms: Genetic Organization of HIV; L. Ratner. T Cell Epitopes in the HIV1 Envelope Glycoprotein; R.F. Siliciano. B Cell in the HIV Glycoproteins; E. Bjoerling, E. Norrby. Lymphocyte Adhesion Coreceptors and Their Roles in HIV1 Replication; J.A. Ledbetter. Immunopathogenesis: HIV and Lymph Node and Thymus; D.D. Patel, et al. Effects of HIV1 and HIV1 Glycoproteins on Signalling Pathways in Human T Lymphocytes; S. Gupta. Lymphocyte Apoptosis in HIV Infection; N. Oyaizu, S. Pahwa. Biological Activities of HIVspecific Peptides; S. Schwartz, et al. Phenotypic Analysis of Lymphocytes and T Cell Functions in HIV Infection; J. Giorgi, J. Nicholson. Cytotoxic T Lymphocyte Responses to HIV: From Seroconversion to AIDS; B. Autran. Type 1 and Type 2 Responses in HIV Infection and Exposure; G. Shearer, M. Clerici. Humoral Immunity to HIV1: Lethal Force or Trojan Horse? P.L. Nara. Autoimmunity in HIV; C. Via, A.R. Sarwari. Cytokine Cascade in HIV Infection; G. Poli, A.S. Fauci. Macrophage Functions in HIV Infection; S. Wahlet, et al. Dendritic Cell Functions in HIV Infection; S.C. Knight.Natural Killer Cells in HIV Infection; B. Bonavida, A. Jewett. HIV and Complement; M.P. Dierich, et al. Polymorphonuclear Leukocyte Function in HIV; S. Shyur, H. Hill. Mucosal Immunity in HIV Infection; H.F. Staats, J.R. McGhee. The Putative Role of HIV1 Envelope Proteins in the Neuroimmunology and Neuropathologyof CNS AIDS; P. Koka, J.E. Merrill. Immunopathogenesis of Kaposi's Sarcoma; R. Gallo, F. Samaniego. Pathogenesis of HIV associated Lymphoma; V.L. Ng, M.S. McGrath. Immunebased Therapy: The Immunotherapy of HIVInfection with Drugs; J. Hadden. Biologic Response Modifiers (Including Interleukins and Interferons); G.A. Fyfe, H.C. Lane. Thymic Hormones in the Treatment of AIDS and Other Infectious Disease; A.L. Goldstein, P.S. Sarin. Growth Factors in the Treatment of Disease; D.T. Scadden, D. Golde. TCell Vaccination for HIVseropositive Patients; H. Atlan, I.R. Cohen. HIV Vaccines; D.P. Bolognesi. Gene Therapy; R.A. Morgan. Index.