Main description:

This practical volume examines a number of topics
that explore the current status of immunotherapy and diagnostic markers for
neurodegenerative disorders. With a focus on Alzheimer's disease, the first
sections of the book examine immunotherapeutic approaches for the
aforementioned disease as well as for Parkinson's disease and Huntington's disease,
amongst others. The last section of the book covers the importance of biomarker
techniques to catch these diseases early enough for the treatments to be most
useful. Written for the Methods in
Pharmacology and Toxicology series, this book contains the kind of detailed
descriptions and implementation advice that will offer a smooth transition into
the lab.

Authoritative and useful, Immunotherapy and Biomarkers in
Neurodegenerative Disorders aims to aid in the continued progress in the
development of novel immune-based drugs and diagnostic tools for these
devastating brain diseases.

Contents:

Part I: Immunotherapy
Against Amyloid-b in
Alzheimer's Disease

1. Immunotherapy Against Amyloid- in Alzheimer's Disease: An Overview

Niels D. Prins

2. Active Immunization Against the
Amyloid- Peptide

Enchi Liu
and J. Michael Ryan

3. Immunotherapy
Against N-Truncated Amyloid- Oligomers

Thomas A.
Bayer and Oliver Wirths

4. Immunotherapy
Against Amyloid- Protofibrils: Opportunities and Challenges

Lars
Lannfelt

Part II:
Immunotherapy in Other Neurodegenerative Disorders

5. Immunotherapy
Against -Synuclein Pathology

Elvira
Valera and Eliezer Masliah

6. Extracellular -Synuclein as a Target for
Immunotherapy

Jun Sung Lee and Seung-Jae Lee

7. Immunotherapy of Parkinson's Disease

Achim Schneeberger,
Suzanne Hendrix, and Markus Mandler

8. Tau Immunotherapy

Einar M. Sigurdsson

9. Active and Passive Immunotherapy Against Tau: Effects and
Potential Mechanisms

Kiran Yanamandra, Marc
I. Diamond, and David M. Holtzman

10. Immunotherapy on Experimental Models for
Huntington's Disease

Anne Messer

Part III: Biomarkers for Neurodegenerative Disorders

11. Cerebrospinal Fluid Biomarkers in Alzheimer's Disease

Henrik Zetterberg and
Jonathan M. Schott

12. Volumetric MRI as a Diagnostic Tool in
Alzheimer's Disease

Eric Westman, Lena Cavalin, and
Lars-Olof Wahlund

13. PET Imaging as a Diagnostic Tool in Alzheimers
Disease

Juha O. Rinne

14. lpha-Synuclein as a Diagnostic
Biomarker for Parkinson's Disease

Joakim Bergstroem and Martin Ingelsson

15. Imaging as a Diagnostic Tool in
Parkinson's Disease

Johan Wikstroem and Torsten Danfors

16. Mass
Spectrometry-Based Proteomics
in Biomarker Discovery for Neurodegenerative
Diseases

Sravani Musunuri,
Ganna Shevchenko, and Jonas Bergquist