Main description:

Incretins are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from cells in the pancreas after eating. Incretin based drugs are used to control blood sugar levels in the management of diabetes.

This book is a concise guide to incretin based therapy. Beginning with an introduction to the history and physiology of incretins, the following sections examine the clinical pharmacology of GLP-1 Analogues and DPP-4 Inhibitors, the pleiotrophic effects of incretins and comparative pharmacology.

Each section integrates science with practical therapeutic guidance for clinicians involved in the management of diabetes. The final chapter discusses the future of incretin therapies, including non-diabetic usage and combination therapy.

Key Features

Concise overview of incretin based therapy for the management of diabetes

Guides clinicians step by step through the history and pharmacology of various molecules
Integrates science with practical therapeutic guidance
Includes chapter on the future of incretin therapy

Contents:

Section 1: Incretins: An Introduction

History of Incretins
Physiology of Incretins
Incretins Hormones: Effects beyond Glycemic Control

Section 2: Clinical Pharmacology of GLP-1 Analogues

GLP-1 Analogues: An Overview
GLP-1 Analogues: Monotherapy
GLP-1 Analogues: Combination Therapy
GLP-1 Analogues and Insulin Combination

Section 3: Clinical Pharmacology of DPP-4 Inhibitors

DPP-4 Inhibitors: An Overview
DPP-4 Inhibitors: Monotherapy
DPP-4 Inhibitors: Combination therapy

Section 4: Pleiotropic Effects of Incretins

Cardiovascular Effects of Incretins
Neurological Effects of Incretins
Gastrointestinal and Hepatobiliary Effects of Incretins
Incretins and Insulin Sensitivity
Incretins and Obesity

Section 5: Comparative Pharmacology

GLP-1 Analogues vs. DPP-4 Inhibitors
Choosing a GLP-1 Analogue
Choosing a DPP-4 Inhibitor
The Future of Incretin Therapies