Main description:

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.

Contents:

Chapter 1: Introduction
Author: Anton Berns (Netherlands Cancer Institute)

Chapter 2: Retroviral mutagenesis in mouse leukemia/lymphoma
Author: David Largaespada, Ph.D. (University of Minnesota)

Chapter 3: MMTV models of breast cancer
Author: John Hilkens (NKI)

Chapter 4: Retroviral mutagenesis in other organisms
Author: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.)

Chapter 5: Sleeping Beauty models of cancer
Author: Adam J. Dupuy, Ph.D. (University of Iowa)

Chapter 6: Insertional mutagenesis in gene therapy patients
Author: David Williams, M.D. (Cincinnati Children's Hospital)

Chapter 7: Bioinformatics of high throughput insertional mutagenesis
Author: Keiko Akagi (NCI-Frederick)