Main description:

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Contents:

IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms.

Karin R. Engelhardt and Bodo Grimbacher

Control of intestinal inflammation by interleukin-10.

Abhisake Kole and Kevin J. Maloy

Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.

Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta and Manuela Battaglia.

Interleukin-10-producing B cells and the regulation of immunity.

Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa and Simon Fillatreau.

Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?

Meghan K. Eberhardt and Peter A. Barry

IL-10: achieving balance during persistent viral infection.

Cherie T. Ng and Michael B.A. Oldstone

The role of microRNAs in the control and mechanism of action of IL-10.

Susan R. Quinn, Luke A. O'Neill

The regulation of IL-10 expression.

Leona Gabrysova, Ashleigh Howes, Margarida Saraiva and Anne O'Garra

The Molecular Basis of IL-10 Function: From Receptor Structure to the Onset of Signaling.

Mark R. Walter

Role of IL-22 in microbial host defense

Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang