Main description:

This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines.

The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Contents:

Part I: Scientific Bases.- From Pasteur to personalized vaccines.- Cell biology & Molecular Biology.- Basic vaccine immunology.- Gut and mucosa immunity.- Pediatric immunology.- Elderly immunology.- Tumor immunology.- Part II: Design of vaccines.- Antigen screening/selection processes.- Modes of action of vaccines.- Types of vaccines.- Adjutants.- Nanotechnologies.- Delivery technologies.- In silico vaccine design.- Infection vaccinology.- NINC vaccines.- Tumor vaccinology.- Vet vaccines.- Part III: Production and Public Health Issues.- Formulation.- Biomanufacturing.- Preclinical and clinical trials: basic principles.- Vaccine safety - assessment of adverse effects.- Ethical issues.- Registration process: Evidence-based vaccine trials.- Future vaccines.