Main description:

Ion-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. The possibilities for this technology continue to grow as novel ion-pair reagents and strategies are introduced at an accelerated level. Compensating for a dearth in the literature, Ion-Pair Chromatography and Related Techniques details the basics and the evolution of this established and easily tunable technique and explains its influence on similar methods.

Theoretical modeling to application

Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in the life science, medicine, pharmacology, forensic, food, and environmental sectors. It examines the upgrade of column technology and instrumentation to improve data quality and to increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques.

Future endeavors

IPC has the potential to have lasting impact in the field of chromatography. Distilling the knowledge gained from preeminent research, this volume is a critical resource that is destined to stimulate future endeavors by separation scientists working in the area of high performance liquid chromatography.

Contents:

Introduction. Electrolyte Solutions and Historical Concept of Ion-Pairing. Retention Modeling as Function of Mobile Phase Composition. Modeling of Retention as a Function of Analyte Nature. Stationary Phases. Developments in Column Technology and Fast IPC. Ion Pairing Reagents. Organic Modifiers. Role of Eluent pH in IPC. Temperature. Special IPC Modes and Variations. Detection and Combination. Examples of Applications. IPC versus Competitive Techniques. Ion-Pairing in Different Analytical Techniques. Non-Separative Applications of IPC. Conclusions and Future Research Needs.