Main description:

This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. The coverage includes the key approaches for drug designand discovery high-throughput screening, fragmentscreening, multi-target drugs, de novo design, ADMET, naturalproducts. This cutting-edge reference helps medicinal chemists inbiotech, pharmaceutical, and other research contexts consider allpossible avenues in starting their drug research programs.

Contents:

PREFACE. CONTRIBUTORS. 1 Lead Discovery: The Process (William F. Michne). 2 High Throughput Screening Approach to Lead Discovery (ZoranRankovic, Craig Jamieson, and Richard Morphy). 3 In Silico Screening (Dagmar Stumpfe, Hanna Geppert, andJurgen Bajorath). 4 Fragment-Based Lead Discovery (Jeffrey S. Albert). 5 Design of Multitarget Ligands (Richard Morphy and ZoranRankovic). 6 De novo Drug Design (Gisbert Schneider, MarkusHartenfeller, and Ewgenij Proschak). 7 Role of Natural Products in Drug Discovery (Hugo Lachance,Stefan Wetzel, and Herbert Waldmann). 8 Early Screening for ADMET Properties (Dennis A.Smith). 9 Role of Chemistry in Lead Discovery (Roland E. Dolle andKarin Worm). INDEX.