Main description:

Molecular recognition undoubtedly governs any aspect of
cellular interaction. To understand tumor cell growth
regulation and spread, analysisof protein carbohydrate
interactions can contribute to lead to the establishment of
rational methods for diagnosis and therapy. Chemically and
biochemically optimized preparation of adequate tools, their
application for localization of receptor (tissue lectin) and
ligand (cellular glycoconjugate) pairs in tumor cells and
tumor sections and the usefulness of a lectin from a plant
extract as potent immunomodulator indicate the prospect for
a place of such techniques in pathology and oncology.

Contents:

Molecular basis of lectin-carbohydrate interactions.- Invertebrate lectins: new aspects in retrospects.- Narcissus and Gerardia lectins: Tools for the development of a vaccine against AIDS and a new ELISA to quantify HIV-gp 120.- Lectin histochemistry of human thyroid tumors.- Neoglycoconjugates: Fundamentals and recent progresses.- Neoglycoproteins and lectins in human lung cancer: A survey.- How to localize ?-galactoside-specific endogenous lectins and their ligands in tissue sections: A comparison of the application of different histochemical tools in breast cancer.- Endogenous receptors for carbohydrate ligands in human renal cell carcinoma.- Brain, nerves and muscles: Neoglycoproteins in the practice of neuromorphology and neuropathology 123.- Site-associated differences in endogenous lectin expression by mouse colon carcinoma cells.- Differentiation-associated modulation of lactose- binding lectins in cancer cells.- Change in metastasis and organotropism of mouse lymphoma variants associated with changes in expression of adhesion molecules and chemotactic responsiveness.- Biomodulation: An integrated approach to access and manipulate biological information.- Immunotherapeutic effects of purified mistletoe lectin (ML-I) on murine large cell lymphoma.- The rationale of mitogenic lectin therapy for cancer.- New perspectives in the treatment of acute myeloid leukemia by hematopoietic growth factors 229.- Enzyme replacement therapy with macrophage-targeted human placental glucocerebrosidase in Gaucher disease.- Preparation of neoglycoprotein-bearing liposomes and their interaction with cells and tissues.- Membrane recognition of steroid-glycoprotein complexes: A model for steroid delivery to the target cells.- Tumor cell-bone marrow stromal cell interaction: Neoglycoproteins as tools in leukemia research.- Cell surface glycans influence the fate of circulating white blood cells.- Fertilization: A model for cell-cell interaction.- Endogenous mannose-binding lectins in brain development and function.