Main description:

Liposome Technology, Volume II: Entrapment of Drugs and Other Materials into Liposomes, Third Edition is a comprehensively updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume II describes procedures for the incorporation of drugs and other materials into liposomes for a variety therapeutics, chosen because of their relevance to current trends in liposome applications or because they represent groups of active pharmaceutical ingredients with similar physical and chemical properties. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

Contents:

Amphipathic Weak Base Loading into Preformed Liposomes Having a Transmembrane Ammonium Ion Gradient: From the Bench to Approved DOXIL. Encapsulation of Drugs within Liposomes by pH Gradient Techniques. Incorporation of Lipophilic Antitumor and Antiviral Drugs into the Lipid Bilayer of Small Unilamellar Liposomes. Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier. An Original Lipid Complex System for Amphotericin B. Coupling of Peptides to the Surface of Liposomes: Application to Liposome-Based Synthetic Vaccines. Encapsulation of Nucleic Acid-Based Therapeutics. Intraliposomal Trapping Agents for Improving In Vivo Liposomal Drug Formulation Stability. Radiolabeling of Liposomes for Scintigraphic Imaging. Liposomal Bisphophonates for the Treatment of Restenosis. Development of a Liposomal Vaccination System for Immunity Modulating Anti-Tumor Therapy. Influenza Virosomes as Adjuvants in Cancer Immunotherapy. Liposome-Based DNA/Protein Vaccines: Procedures for Entrapment. LPD: A Non-Viral Gene Vector Turned into a Potent Vaccine Carrier. Automated Screening of Cationic Lipid Formulations for Transfection. Association of Neutral or Anionic PEG Lipids into Lipoplexes: On Line Incorporation Assessment, and Pharmacokinetics Advantages. Lipid Peptide Vectors for Gene Therapy. Phospholipid and Non-Phospholipid Based Vesicles for Drug and DNA Delivery to Mitochondria in Living Mammalian Cells. Uptake and Intracellular Fate of Liposomes.