Contents:

Assessment of Lymphocyte Clonality- historical overview of molecular methods for gene rearrangement. 10 pages Clonality in Lymphomagenesis-Natural History of Lymphomas. 10 pages Significance of Clonality in Lymphoma Diagnosis-Description of typical laboratory workup. 10 pages Case Studies-20 to 25 cases (100 pages) each with its own subheading, which include: Patient history Microscopic image(s) Flow results Electropherograms of gene rearrangements Other pertinent data Interpretation Translational Research & Lymphocyte Clonality-Discussion of research (10 pages), which includes: Method improvement Pathologic questions regarding lymphocyte clonality Future Applications- (10 pages) will include discussion on: Added benefit of more primer sets Benefit of different platforms for tissue extraction & analysis Need of clonality assay in other cell lineages such as NK cells?