Main description:

This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.

Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.

Contents:

Table of Contents
Macropinocytosis - Functions and Mechanisms
Preface
Part 1: Functions of Macropinocytosis1. Functional Diversity of Macropinocytosis - Mishra et al. 2. Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways - Lambies et al.3. The amoebal model for micropinocytosis - Kay et al.4. Extracellular ATP and macropinocytosis - Evers et al.5. Macropinocytosis and Cell Migration: Don't drink an drive - Delgado et al. 6. Macropinocytosis in phagocyte function and immunity - Canton et al.
Part 2: Signaling Mechanisms Driving Macropinocytosis7. Roles of 3' Phosphoinositides in Macropinocytosis - Swanson et al.8. Signaling pathways that regulate macropinocytosis in mammalian cells - Palm9. Wnt, GSK3 and Macropinocytosis - Munoz et al.10. Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis - Seguin et al. 11. Kras-independent macropinocytosis in pancreatic cancer - Hobbs et al.