Main description:

This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analyzing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice.

Management of Hypertension: Current Practice and the Application of Landmark Trials is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research.

Contents:

SECTION ONE: INTRODUCTION TO MEDICAL RESEARCH

1. The importance of applying evidence-based medicine in clinical practice.

2. How to read and understand a scientific paper?

3. Medical Biostatistics; The basics

SECTION TWO: MAJOR TRIALS IN HYPERTENSION RESEARCH

4. Is blood pressure related to increased cardiovascular risk?

5. The VA Cooperative Studies - The First RCTs of Hypertension anywhere in the world.

6. What is the role of dietary modifications in controlling blood pressure?

7. Hypertension management in the elderly

8. Hypertension management in African Americans

9. Hypertension management in diabetics

10. Outcomes of different antihypertensive regimens

11. Comparison of combination therapies in the treatment of hypertension

12. What is the goal of treatment?

13. Can we prevent hypertension?

SECTION THREE: BLOOD PRESSURE ASSESSMENT METHODS USED IN LANDMARK TRIALS

14. Methods of blood pressure assessment used in milestone hypertension trials

SECTION FOUR: PIONEERS IN HYPERTENSION RESEARCH

15. Marvin Moser

16. Irvine Page

17. Edward Freis

18. Stevo Julius

SECTION FIVE: CLOSING REMARKS

19. The Future in Hypertension Research