Main description:

This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.

Contents:

Table of Contents

"Castration Resistant Prostate Cancer"

Editors: K.C Balaji

Ch. 1: Introduction

K.C Balaji

Ch. 2: Pathophysiology of Castration-Resistant Prostate Cancer

Justin C. Penticuff

Natasha Kyprianou

Ch. 3: Androgen Receptor Signaling in Castration Resistant Prostate Cancer

Yu Zhao

Donald J. Tindall

Haojie Huang

Ch. 4: Non-Androgen Signaling Pathways in Castration-Resistant Prostate Cancer

Sivanandane Sittadjody

Thilakavathy Thangasamy

Bita NickKolgh

K.C. Balaji

Ch. 5: Predictive Models in Castration Resistant Prostate Cancer

Tao Cui

Michael W. Kattan

Ch. 6: Docetaxel in Advanced and Castration Resistant Prostate Cancer

Daniel P. Petrylak

Navid Hafez

Ch. 7: Combination Treatment Strategies with Docetaxel in Patients with Metastatic Prostate

Ben Fulton

Robert J. Jones

Ch. 8: Cancer Vaccines in Castration Resistant Prostate Cancer - An evolution in design

Susan F. Slovin

Ch. 9: Abiraterone for the treatment of mCRPC

Zafeiris Zafeiriou

Niven Mehra

Johann S. de Bono

Ch. 10: Enzalutamide in Metastatic Castration Resistant Prostate Cancer

Jeffrey Shevach

Bridget K. Marcellino

William K. Oh

Che-Kai Tsao

Ch. 11: Radium-223 in Metastatic Castrate Resistant Prostate Cancer

Tu Dan

Robert B. Den

Ch. 12: Cabazitaxel for the Treatment of Prostate Cancer

Michael Kolinsky

Niven Mehra

Johann S. de Bono

Ch. 13: Sequencing Therapies in Metastatic Castration Resistant Prostate Cancer

Michael T. Schweizer

Bruce Montgomery

Ch. 14: Bone Preservation Strategies for Men on Androgen Deprivation Therapy

Charles C. Peyton

K. C. Balaji

Ch. 15: Novel Therapies in Castration-Resistant Prostate Cancer

Tyler Lash

Rhonda L. Bitting