Main description:

Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson's Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo.

Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks.

Contents:

1. Alpha-synuclein spreading mechanisms in Parkinson's disease: The role of membrane receptors

Ines C. Bras and Tiago F. Outeiro

2. Modeling synucleinopathies in rodents

Anna Barber Janer, Eline Vonck and Veerle Baekelandt

3. Spreading of alpha-synuclein pathology from the gut to the brain in Parkinson's disease

Benjamin Jevans and Donato A. Di Monte

4. PINK1: Multiple mechanisms of neuroprotection

Britney N. Lizama, P. Anthony Otero and Charleen T. Chu

5. Mechanisms of VPS35-mediated neurodegeneration in Parkinson's disease

Dorian Sargent and Darren J. Moore

6. Mechanisms of cell death and approaches to neuroprotection/disease modification in Parkinson's disease

Alexis Martinez, Maria Jesus Cerna, Romina Gozalvo and Claudio Hetz

7. Immune response during idiopathic Parkinson's disease: From humans to animal models

Sara Konstantin Nissen, Sara A. Ferreira, Ida Klaestrup and Marina Romero-Ramos