Main description:

Comprehensive and current, this one-of-a-kind resource offers students and practitioners an ideal reference in therapeutic drug decision-making. "Melmon and Morrelli's Clinical Pharmacology" builds the necessary links among scientific principles, fact-based evidence, and clinical experience. Designed to aid physicians at all levels in improving the quality of treatment and providing optimal pharmotherapeutic plans for patients, this resource outlines a problem-based approach to drug therapy that emphasizes the rationale behind it. Fully updated to keep pace with advances in medicine, "Melmon and Morrelli's Clinical Pharmacology" is 75 per cent new and substantially revised, with new coverage of antimicrobials, drug kinetics and dynamics, drug interactions, and more.With chapters written by leading international experts in many therapeutic fields, this resource provides: in-depth discussions of the principles of therapeutic choice that apply across multiple types of treatment; chapters on drug treatments for pulmonary, infectious, cardiovascular, psychiatric, hematologic diseases, and other areas frequently encountered in internal medicine; coverage of special-case scenarios, such as stages of life and patients with various drug needs; and, easy-to-find practical information on evidence of effectiveness, toxicity, cost/benefit ratios, acute effects, and long-term outcomes.

Contents:

Introduction. Introduction to Clinical Pharmacology and Rational Therapeutics. Drug Therapy of Common Diseases: Problem-Based Therapeutic Decisions. Cardiovascular Disorders. Respiratory Disorders. Gastrointestinal Disorders. Hepatic Disorders and the Influence of Liver Function on Drug Dispostion. Nutrition. Renal Disorders and the Influence of Renal Function on Drug Disposition. Neurologic Disorders. Psychiatric Disorders. Endocrine and Metabolic Disorders. Connective Tissue and Bone Disorders. Dermatologic Disorders. Hemtalogic Disorders. Oncologic Disorders. Infectious Disorders. Conscious Sedation and Pain. Treatment in the Intensive Care Unit. Substance Abuse: Dependence and Treatment. Poisoning. Core Topics in Clinical Pharmacology. Drug Therapy in Pregnant and Breast-Feeding Women. Geriatric Pharmacology. Pharmacogenetics. Clinical Pharmacokinetics and Pharmacodynamics. Adverse Drug Reactions. Drug Interactions. Writing Prescriptions. Drug Discovery and Development. Risk Analysis Applied to Prescription Drugs. The Clinician's Actions When N = 1. Information About Drugs: A Clinical Epidemiologic Approach to Therapeutics.