Main description:

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented.

Contents:

Editorial: Metal-Related Neurological Disorders: Several New Genes and Better Understanding
Susanne A. Schneider and Kailash P. Bhatia

The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations
Kurt A. Jellinger

Pantothenate Kinase-Associated Neurodegeneration (PKAN) and PLA2G6-Associated Neurodegeneration (PLAN): Review of Two Major Neurodegeneration with Brain Iron Accumulation (NBIA) Phenotypes
Manju A. Kurian and Susan J. Hayflick

Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN)
Monika Hartig, Holger Prokisch, Thomas Meitinger and Thomas Klopstock

BPAN: The Only X-Linked Dominant NBIA Disorder
Tobias B. Haack, Penny Hogarth, Allison Gregory, Holger Prokisch and Susan J. Hayflick

Neuroferritinopathy
Michael J. Keogh, Christopher M. Morris and Patrick F. Chinnery

Aceruloplasminemia-An Update
Satoshi Kono

Therapeutic Advances in Neurodegeneration with Brain Iron Accumulation
Giovanna Zorzi and Nardo Nardocci

The Neuropathology of Neurodegeneration with Brain Iron Accumulation
Michael C. Kruer

Imaging of Iron
Petr Dusek , Monika Dezortova and Jens Wuerfel

The Role of Iron Imaging in Huntington's Disease
Simon J. A. van den Bogaard, Eve M. Dumas and Raymund A.C. Roos

Lysosomal Storage Disorders and Iron
Jose Miguel Bras

Manganese and the Brain
Karin Tuschl, Philippa B. Mills and Peter T. Clayton

Update on Wilson Disease
Annu Aggarwal and Mohit Bhatt

An Update on Primary Familial Brain Calcification Roberta R. Lemos, J. B. M. M. Ferreira, Matthew P. Keasey and Joao R. M. Oliveira