Main description:

Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Contents:

Part One The Problem

Chapter 1 Bone Metastases: Epidemiology and Societal Effect

Robert U. Ashford and R. Lor Randall

Part Two Biology of Metastases and Tissue of Origin Considerations

Chapter 2 Pathobiology of Osteolytic and Osteoblastic Bone Metastases

Antonella Chiechi and Theresa A. Guise

Chapter 3 Biology of Bone Cancer Pain

Patrick W. O'Donnell and Denis R. Clohisy

Chapter 4 Breast Cancer Bone Metastases

Sarah Colonna and Theresa L. Werner

Chapter 5 Prostate Cancer Bone Metastasis

Jonathan D. Tward

Chapter 6 Lung

Shamus R. Carr

Chapter 7 Kidney Metastatic Bone Disease

Patrik Luzny and Christopher Dechet

Chapter 8 Thyroid

Elie Klam and Dev Abraham

Chapter 9 Myeloma

Srinivas K. Tantravahi and Tibor Kovacsovics

Part Three Work-Up for Patients with Suspected Metastatic Bone Disease

Chapter 10 Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone

Bruce T. Rougraff and Terence J. Cudahy

Chapter 11 Biopsy Considerations

Daniel M. Lerman

Part Four Medical Therapy

Chapter 12 Bisphosphonates, Denosumab and Anabolic Agents in the Treatment of Metastatic Bone Disease

Z. Deniz Olgun, Arianna Gianakos, Jonathan E. Jo, Joseph M. Lane

Chapter 13 Biotargeting in Metastatic Bone Disease

Anna R. Cooper, Wakenda Tyler, and Emily E. Carmody

Part Five Supportive Oncology

Chapter 14 Psychosocial Considerations for Patients with Metastatic Bone Disease

Amy Horyna

Chapter 15 Pain Management in Metastatic Bone Disease

Shane E. Brogan and Daniel W. Odell

Chapter 16 When is Hospice Appropriate? The Role for Hospice in Palliating Patients with Bone Metastases

Andrew Badke and Anna C. Beck

Part Six Radiation Oncology

Chapter 17 Current and Emerging Modalities

Hilary P. Bagshaw and Jonathan D. Tward

Part Seven Interventional Oncology

Chapter 18 Ablation and Cementation Technologies

Aaron E. Frodsham and Laura B. Eisenmenger

Part Eight Principles of Orthopaedic Surgical Oncology

Chapter 19 Issues Facing the Established Metastatic Bone Disease Patient, Timing/Indications for Surgery

George T. Calvert

Chapter 20 Questions to Ask Your Medical Oncology Colleagues

Noah Federman, Amanda Loftin, and Nicholas M. Bernthal

Chapter 21 Consideration of the Temporal Relationship between Surgery and Radiation Therapy

Daniel M. Lerman

Chapter 22 Role of Surgery in Oligometastatic Disease

George T. Calvert

Part Nine Specific Anatomic Considerations for Surgery

Chapter 23 Metastatic Bone Disease: Pelvis

Vishal Hegde and Nicholas M. Bernthal

Chapter 24 Metastatic Bone Disease: Femur

Shawn L. Price

Chapter 25 Metastatic Bone Disease: Femur: Tibia

Nicholas P. Webber

Chapter 26 Metastatic Bone Disease: Foot

Judd E. Cummings

Chapter 27 Metastatic Bone Disease: Femur: Humerus, Scapula

Michael J. Monument and Shannon K.T. Puloski

Chapter 28 Metastatic Bone Disease: Forearm, Hand

Russell Ward

Chapter 29 Metastatic Bone Disease: Spine

Matthew W. Colman and William Ryan Spiker

Part Ten Emerging Surgical Technologies

Chapter 30 Intraoperative Imaging and Navigation

John A. Abraham and Christina J. Gutowski

Part Eleven Putting it All Together

Chapter 31 Integrative Approach with the Patient in Mind: A Glance Forward

R. Lor Randall