Main description:

International biobank collaborations allow for studies with large number of subjects where generalizability of findings across populations can be investigated, which means establishing quality criteria concerning the nature of the sample, conditions of sample storage, and the adequacy of available information is of vital importance. Methods in Biobanking brings together contributions from experts in the field in order to aid in the establishment of this much needed consistency. The volume discusses how to use existing collections of biological material to answer significant questions concerning the cause of disease without violating the personal integrity of participating sample donors, the ethical issues surrounding biobanks, guidelines for the use of coding systems and the use of biocomputing and registry linkages in research projects, as well as many other key subjects. As a volume in the highly successful Methods in Molecular Biology (TM) series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Methods in Biobanking seeks to provide scientists with the tools necessary to take advantage of the tremendous current resources of the world's biobanks and strengthen those resources for the future.

Contents:

1. Genetic Research and Biobanks
Don Chalmers

2. The Need to Down Regulate: A Minimal Ethical Framework for Biobank Research
Mats G. Hansson

3. Nordic Biological Specimen Bank Cohorts as Basis for Studies of Cancer Causes and Control: Quality Control Tools for Study Cohorts with More than 2 Million Sample Donors and 100,000 Prospective Cancers
Eero Pukkala

4. Biobanks Collected for Routine Healthcare Purposes: Build-Up and Use for Epidemiological Research
Joakim Dillner and Kristin Andersson

5. Biobanks and Registers in Epidemiological Research on Cancer
Eero Pukkala

6. Study Designs for Biobank-Based Epidemiologic Research on Chronic Diseases
Esa Laara

7. The EPIC Biobank (European Prospective Investigation into Cancer and Nutrition)
Pierre Hainaut, Beatrice Vozar, Sabina Rinaldi, Elio Riboli, and Elodie Caboux

8. The AIDS and Cancer Specimen Resource (ACSR)
Leona W. Ayers, Sylvia Silver, Jan M. Orenstein, Michael S. McGrath, and Debra L. Garcia

9. Specific Advantages of Twin Registries and Biobanks
Jaakko Kaprio

10. The Swedish Multi-Generation Register
Anders Ekbom

11. Multigenerational Information: The Example of the Icelandic Genealogy Database
Hrafn Tulinius

12. Creation of a New Prospective Research Biobank: The Example of HUNT3
Kristian Hveem

13. Best Practices for Establishing a Biobank
Goeran Hallmans and Jimmie B. Vaught

14. Extraction, Quantitation, and Functionality Evaluation of DNA from Various Sample Types
Malin Ivarsson and Joyce Carlson

15. Cervical Cytology Biobanks as a Resource for Molecular Epidemiology
Marc Arbyn, Kristin Andersson, Christine Bergeron, John-Paul Bogers, Magnus von Knebel-Doebertitz, and Joakim Dillner

16. Biobanking of Fresh Frozen Tissue from Clinical Surgical Specimens: Transport Logistics, Sample Selection, and Histological Characterization
Johan Botling and Patrick Micke

17. Protein Extraction from Solid Tissue
Christer Ericsson and Monica Nister

18. Collection and Preservation of Frozen Microorganisms
Rosamaria Tedeschi and Paolo De Paoli

19. Handling of Solid Brain Tumor Tissue for Protein Analysis
Christer Ericsson and Monica Nister

20. Blood Plasma Handling for Protein Analysis
Christer Ericsson and Monica Nister

21. Biobank Informatics: Connecting Genotypes and Phenotypes
Jan-Eric Litton

22. A Practical Guide to Constructing and Using Tissue Microarrays
Ian Chandler, Richard Houlston, and Goran Landberg

23. Breast Cancer Genomics Based on Biobanks
Asta Foersti and Kari Hemminki

24. Monitoring, Alarm, and Data Visualization Service on Sample Preparing and Sample Storing Devices in Biobanks
Halla Hauksdottir, Kristin Jonsdottir, and Andres Thorarinsson

25. Fresh Frozen Tissue: RNA Extraction and Quality Control
Johan Botling and Patrick Micke