Main description:

This second edition brings together up-to-date contributions
from leaders in the field internationally on the various ways in which
mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative
diseases, including Parkinson's disease, Alzheimer's disease and multiple
sclerosis. The reader is guided through the basic functions of mitochondria and
the mechanisms that lead to their dysfunction, and on to the consequences of
this dysfunction for neuronal function before finishing with the modelling of
these disorders and discussion of new potential therapeutic targets.

Additional chapters have been added to the book to reflect
advances in the field and there are many new contributors and topics, including
how mitochondria are degraded and the interaction of the mitochondria with
pathologically relevant proteins.

Mitochondrial Dysfunction in Neurodegenerative Disorders
provides an accessible, authoritative guide to this important area for
neurologists; research and clinical neuroscientists; neuropathologists; and
residents with an interest in clinical research.

Contents:

Part I.
Mitochondria and Neurodegenerative Disease.- An Introduction
to Mitochondria, Their Structure and Functions.- Part II.
Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain,
Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- Mitochondrial
Signalling and Neurodegeneration.- Part III. Functional Consequences of
Mitochondrial Dysfunction.- Life on the Edge: Determinants of Selective
Neuronal Vulnerability in Parkinson's Disease.- Mitochondrial
Dynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.-
Mitochondria,
the Synapse, and Neurodegeneration.- Protein Misfolding and
Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.-
Mitochondrial Degradation, Autophagy and
Neurodegenerative Disease.- The Deleterious
Duo of Neurodegeneration: Lysosomes and Mitochondria.- Part IV. Measuring the
Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- Can
We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- Mitochondrial
Function and Dynamics Imaged In Vivo.-
Part V. The Future.- Development
of Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.