Main description:

This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice.

Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.

Contents:

1. Why cytology for molecular testing? Pros and ConsLukas Bubendorf 2. How to prepare cytological samples for molecular testing Claudio Bellevicine, Umberto Malapelle, Elena Vigliar, Pasquale Pisapia, Carlo Ruosi, Giancarlo Troncone3. Molecular tests use in cytological material (analytical phase)Zsofia Balogh, Philippe Vielh 4. Molecular cytology applications on Head and NeckMarc P. Pusztaszeri, Joaquin J. Garcia, William C. Faquin 5. Molecular cytology applications on LungAlessia Di Lorito, Daniel Stieber, Fernando C. Schmitt6. Molecular Cytology of Serous EffusionsBen Davidson 7. Molecular cytology applications on UrineSpasenija Savic 8. Molecular cytology applications on Gynecological cytologyFrancesca Carozzi, Giovanni Negri, Cristina Sani 9. Molecular Applications in Hematolymphoid CytologyJoerg Schwock, Graeme Quest, William R. Geddie10. Molecular Cytology Application on ThyroidEsther Diana Rossi, Massimo Bongiovanni 11. Molecular cytology applications on Pancreas and Biliary TractRene Gerhard, Roseann I. Wu, Norge Vergara 12. Molecular cytology applications in Soft tissue (Pediatric tumors)Kossivi E. Dantey, Sara Monaco 13. Molecular cytology applications in metastasesFrancisco Beca, Fernando Schmitt 14. Clinical integration of molecular results on cytology (post-analytical phase)Perry Maxwell, Fernando Schmitt, Manuel Salto-Tellez