Main description:

Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens

As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes.

Contents:

Regulation and Evolution of the RAG Recombinase
Grace Teng and David G. Schatz
Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly
Gita Kumari and Ranjan Sen
Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci
Anja Ebert, Louisa Hill and Meinrad Busslinger
Long Range Regulation of V(D)J Recombination
Charlotte Proudhon, Bingtao Hao, Ramya Raviram, Julie Chaumeil and Jane A. Skok
Dynamic Control of Long-range Genomic Interactions at the Immunoglobulin ? Light Chain Locus
Claudia Ribeiro de Almeida, Rudi W. Hendriks and Ralph Stadhouders
Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms
Kinjal Majumder, Craig H. Bassing and Eugene M. Oltz
Chromatin Dynamics and the Development of the TCRa and TCRd Repertoires
Zachary Carico and Michael S. Krangel
Long-range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views
Pernelle Outters, Sebastien Jaeger, Nancy Zaarour and Pierre Ferrier