Main description:

The biomolecular basis underlying essential hypertension and end organ damage associated with hypertension is characterized as polygenic diseases with complexities such as "environment gene" and "gene-gene" interactions. Despite intensive research in this field, this molecular book is aimed at providing the state-of-the-art reviews which define how the biologic systems sense changes in environment, alter their activities or function, and cross talk with other neurohormonal systems to modulate cardiovascular/renal function and blood pressure. This title will attract scientists and investigators in both academic and industrial fields, and clinicians.

Contents:

The DEG/ENaC Family.- The Role of DEG/ENaC Ion Channels in Sensory Mechanotransduction.- ASICs Function as Cardiac Lactic Acid Sensors During Myocardial Ischemia.- Molecular Components of Neural Sensory Transduction.- The TRP Family.- TRP Channels as Molecular Sensors of Physical Stimuli in the Cardiovascular System.- TRPV1 in Central Cardiovascular Control.- TRPV1 as a Molecular Transducer for Salt and Water Homeostasis.- Functional Interaction Between ATP and TRPV1 Receptors.- TRPV4 and Hypotonic Stress.- Other Ion Channels and Biosensors.- Ion Channels in Shear Stress Sensing in Vascular Endothelium.- Redox Signaling in Oxygen Sensing by Vessels.- Impedance Spectroscopy and Quartz Crystal Microbalance.