Main description:

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers.

Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Contents:

Introduction
Translating targeted radiosensitizers into the clinic [include focus on normal tissue toxicity
Mechanisms and markers of clinical radioresistance
Pre-clinical screening of targeted radiosensitizers
3D radiation biology for studying radiosensitizers

In vivo determinations of local tumor control and radiosensitzers

GEMMs for studying radiosensitizers
Pre-clinical models for studying radioresistance of GBM [include focus on PD/PK]
Targeting the DNA damage response for radiosensitization [include focus on scheduling]
Targeting metabolomics to overcome radioresistance
Targeting cancer stem cells to overcome radioresistance

Genomic biomarkers of radiation response

Targeting the microenvironment

Radiosensitizers in the era of immuno-oncology