Main description:

Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers.

Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.

Contents:

Part 1: Molecular approaches and techniques

Chapter 1: Transitioning Diagnostic Molecular Pathology to the Genomic Era: Cancer Somatic Mutation Panel Testing

Kitchener D. Wilson and Iris Schrijver

Chapter 2: Conventional and Molecular Cytogenetics in Cancer

Michelle Dolan

Chapter 3: Comparative Genomic Hybridization and Array based CGH in Cancer

Roland Hubaux, Victor D. Martinez, David Rowbotham, and Wan L. Lam

Chapter 4: Polymerase Chain Reaction

Maria Pasic, Carlo Hojilia, and George M. Yousef

Chapter 5: Single Nucleotide Polymorphisms (SNPs)

Jyotsna Batra, Srilakshmi Srinivasan, and Judith Clements

Chapter 6: Clinical Application of DNA Sequencing: Sanger and Next-Generation Platforms

John D. McPherson

Chapter 7: Microarray-based Investigations in Cancer

Maud H.W. Starmans, Syed Haider, Cindy Yao, Philippe Lambin, and Paul C. Boutros

Chapter 8: Proteomics in Cancer Diagnostics

Kevin P. Conlon, Delphine Rolland, Kojo S. J. Elenitoba-Johnson

Chapter 9: Circulating Tumor Cells: A Non-Invasive Liquid Biopsy in Cancer

Evi S. Lianidou

Part 2: Molecular applications in various malignancies

Chapter 10: Molecular Testing in Hematological Malignancies

Amir Behdad, Bryan L. Betz, Megan S. Lim, and Nathanael G. Bailey

Chapter 11: Molecular Testing in Breast Cancer

Dimitrios Zardavas, Debora Fumagalli, and Christos Sotiriou

Chapter 12: Molecular Pathology of Gastrointestinal Tumors

Andrea Grin and Serge Jothy

Chapter 13: Molecular Testing in Pulmonary Tumors

Jeffrey J. Tanguay, Shirin Karimi, David M. Hwang, and Ming-Sound Tsao

Chapter 14: Molecular testing in Gynecological Malignancies

Pamela M. Ward and Louis Dubeau

Chapter 15: Molecular Testing in Central Nervous System tumors

Jason Karamchandani

Chapter 16: Molecular Testing in Adult Kidney Tumors

Manal Y. Gabril and George M. Yousef

Chapter 17: Molecular Testing in Prostate Cancer

Manal Y Gabril and George M Yousef

Chapter 18: Molecular Testing in Urothelial Tumors

Manal Y Gabril and George M Yousef

Chapter 19: Molecular Testing in Thyroid Cancer

Matthew T. Olson, Jason D. Prescott, and Martha A. Zeiger

CHapter 20: Molecular Testing of Head and Neck Tumors

Diana Bell and Ehab Y. Hanna

Chapter 21: Molecular Testing in Bone and Soft Tissue Tumors

Brendan C. Dickson, Gino R. Somers, Rita A. Kandel

Chapter 22: Molecular testing in Cutaneous Melanoma

Margaret Redpath, Leon van Kempen, Caroline Robert, and Alan Spatz

Chapter 23: Molecular Testing in Pediatric Tumors

Gino R. Somers and Paul S. Thorner

Chapter 24: Pharmacogenomics in Molecular Oncology

Gregory J. Tsongalis

Chapter 25: Quality Assurance in Molecular Testing of Cancer

Sylviane Olschwang, Simon Patton, Etienne Rouleau, and Elisabeth Dequeker