Main description:

Leslie T. Cooper, Jr., MD, and a panel of leading clinical and scientific experts comprehensively review both advances in basic scientific understanding and current clinical knowledge of inflammatory heart disease. On the clinical side they discuss the diagnosis, prognosis, and treatment of nonspecific and specific myocarditis in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis, Chagas disease, rheumatic fever, and human immunodeficiency virus-related cardiomyopathy. Research articles complete the picture with discussions of the role of apoptosis in viral myocarditis, rat and mouse models of autoimmune giant cell and lymphocytic myocarditis, and the latest available data on enteroviral proteases and cardiomyopathy.

Contents:

Introduction and Historical Perspective on Experimental Myocarditis
Charles J. Gauntt

The Primary Viruses of Myocarditis
Kyung-Soo Kim, Katja Hoefling, Steven D. Carson, Nora M. Chapman, and Steven Tracy

Cellular Autoimmunity in Myocarditis
Sally A. Huber

Humoral Immune Response in Viral Myocarditis
Bernhard Maisch and Arsen D. Ristic

Cytokines in Experimental Myocarditis
Akira Matsumori

Nitric Oxide Signaling in Myocarditis
Joshua M. Hare and Charles J. Lowenstein

Life and Death Signaling Pathways in CVB3-Induced Myocarditis
Bobby Yanagawa, Mitra Esfandiarei, Chris Carthy, Paul Cheung, Honglin Luo, David Granville, Decheng Yang, Jonathan Choy, Amy Lui, Darya Dabiri, Janet E. Wilson, Aikun Wang, Mary Zhang, Simon Sinn, Bruce M. McManus, Kevin Wei, Ismail Laher

Animal Models of Autoimmune Myocarditis
Makoto Kodama, Yuji Okura, Yoshifusa Aizawa, and Tohru Izumi

Progression of Myocarditis to Dilated Cardiomyopathy: Role of the Adrenergic System and Myocardial Catecholamines
Petar M. Seferovic, Arsen D. Ristic, and Ruzica Maksimovic

Pathogenesis of Enteroviral Cardiomyopathy: Interaction of Viral Proteins With Infected Myocytes
Dingding Xiong, Cornel Badorff, and Kirk U. Knowlton

Introduction to Clinical Myocarditis
G. William Dec

Use of Cardiac Biomarkers for Detection of Myocarditis
Allan S. Jaffe

Molecular Biologic Detection of Virus Infection in Myocarditis and Dilated Cardiomyopathy
Karin Klingel

Pathology of Human Myocarditis
Gerald J. Berry and Kristen A. Atkins

Endomyocardial Biopsy in Myocarditis
Joseph G. Murphy, and Robert P. Frantz

Treatment of Lymphocytic Myocarditis
Jay W. Mason

Idiopathic Giant Cell Myocarditis
Leslie T. Cooper, Jr.

Cardiac Sarcoidosis
Leslie T. Cooper,Jr.

The Eosinophil in Cardiac Disease
Lambert A. Wu, Leslie T. Cooper, Jr., Gail M. Kephart, and Gerald J. Gleich

Chagas Heart Disease
James M. Hagar and Shahbudin H. Rahimtoola

Cardiac Involvement in Acute Rheumatic Fever
Jagat Narula, Ragavendra Baliga, Navneet Narula, Prem Chopra, and Y. Chandrashekhar

Myocarditis Associated With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
Lyle J. Olson

Childhood Myocarditis and Dilated Cardiomyopathy
Neil E. Bowles and Jeffrey A. Towbin

Peripartum Cardiomyopathy
Joseph G. Murphy

Index