Main description:

This book provides an overview of nanoparticulate drug delivery systems, their potential applications and limitations. The chapters focus on new approaches, manufacturing methodologies, and applications of nanotechnology in drug delivery. Chapter 1 provides an overview of targeted nanomedicine and ddresses strategies developed to overcome limitations of existing systems. It covers a variety of specific topics like dendrimer-based drug delivery, the new liposome system, polymeric nanoparticle systems, and nanocrystals. Part 2 covers preclinical and clinical applications of nanoparticulate systems that have identified their new potentials or biological barriers interfering with the delivery. Each chapter reviews state-of-the-art topics, includes extensive references, and assesses challenges in the field. Overall, this book delivers up-to-date information on nanoparticulate drug delivery systems for students, researchers and professionals in the pharmaceutical, biomedical engineering, and related health sciences industries.

Contents:

Preface vii Contributors ix 1 Tumor-Targeted Nanoparticles: State-of-the-Art and Remaining Challenges 1 Gaurav Bajaj and Yoon Yeo 2 Applications of Ligand-Engineered Nanomedicines 21 Gayong Shim, Joo Yeon Park, Lee Dong Roh, Yu-Kyoung Oh, and Sangbin Lee 3 Lipid Nanoparticles for the Delivery of Nucleic Acids 51 Yuhua Wang and Leaf Huang 4 Photosensitive Liposomes as Potential Targeted Therapeutic Agents 81 David H. Thompson, Pochi Shum, Oleg V. Gerasimov, and Marquita Qualls 5 Multifunctional Dendritic Nanocarriers: The Architecture and Applications in Targeted Drug Delivery 101 Ryan M. Pearson, Jin Woo Bae, and Seungpyo Hong 6 Chitosan-Based Nanoparticles for Biomedical Applications 129 Heebeom Koo, Kuiwon Choi, Ick Chan Kwon, and Kwangmeyung Kim 7 Polymer Drug Nanoconjugates 151 Rong Tong, Li Tang, Nathan P. Gabrielson, Qian Yin, and Jianjun Cheng 8 Nanocrystals Production, Characterization, and Application for Cancer Therapy 183 Christin P. Hollis and Tonglei Li 9 Clearance of Nanoparticles During Circulation 209 Seung-Young Lee and Ji-Xin Cheng 10 Drug Delivery Strategies for Combating Multiple Drug Resistance 241 Joseph W. Nichols and You Han Bae 11 Intracellular Trafficking of Nanoparticles: Implications for Therapeutic Efficacy of the Encapsulated Drug 261 Lin Niu and Jayanth Panyam 12 Toxicological Assessment of Nanomedicine 281 Hayley Nehoff, Sebastien Taurin, and Khaled Greish Index 307