Main description:

Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases. In addition, the authors discuss the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists.

Contents:

Preface.- Acknowledgments.- Glutamate and Aspartate in Brain.- Excitatory Amino Acid Receptors in Brain.- Multiplicity of Glutamate Receptors in Brain.- Glutamate Transporters and their Role in Brain.- Excitatory Amino Acid Receptors and their Association with Neural Membrane Glycerophospholipid Metabolism.- Glutamate Receptors and their Association with Other Neurochemical Parameters in Excitotoxicity.- Possible Mechanisms of Neural Injury Caused by Glutamate and its Receptors.- Glutamate Receptors and Neurological Disorders.- Endogenous Antioxidant Mechanisms and Glutamate Neurotoxicity.- Glutamate Receptor Antagonists and the Treatment of Neurological Disorders.- Future Perspectives: New Strategies for Antagonism of Excitotoxicity, Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases.- Index.