Main description:

Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Contents:

Background: 1 Neuropathological Advances in Multiple Sclerosis.- 2 Neurophysiology.- MRI Techniques to Assess Neurodegeneration: 3 Atrophy.- 4 T1 Black Holes and Gray Matter Damage.- 5 Magnetization Transfer Imaging.- 6 Perfusion MRI.- 7 Diffusion-Weighted Imaging.- 8 Proton MR Spectroscopy.- 9 Functional MRI.-Evaluation of MRI Outcomes: 10 Validation of MRI Surrogates.- 11 Defining Responders and Non-responders.-12 Predictive Models in Multimodal Imaging.- Lessons from other Neurodegenerative Diseases: 13 Alzheimer's Disease.- 14 Other Neurodegenerative Conditions.- 15 Incorporation of Other Biomarkers.- Designing MS Trials for Neurodegeneration.- 16 Critical Review of Existing Trials.- 17 Design for the Next Trials of Neurodegeneration.- Subject Index