Main description:

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer's disease, Parkinson's disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Contents:

Part 1: Mechanisms of Brain Defense and Neuropathogenesis
Chapter 1: The Blood Brain Barrier
Victor Castro, Michal Toborek

Chapter 2: Immune Cell Trafficking in the Central Nervous System
Beena John, Christopher A. Hunter, Tajie H. Harris

Chapter 3: General Physiology and Pathophysiology of Microglia
Alexei Verkhratsky, Mami Noda

Chapter 4: Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases
Gordon P. Meares, Etty N. Benveniste

Chapter 5: Oxidative stress, neuroinflammation, and neurodegeneration
Hui-Ming Gao, Hui Zhou, Jau-Shyong Hong

Chapter 6: Peripheral Neuroimmune Interactions and Neuropathic Pain
Halina Machelska

Part 2: Neurological Diseases and Inflammation
Chapter 7: Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson's Disease
Rebecca A. Wilshusen, R. Lee Mosley

Chapter 8: Multiple sclerosis: impact on functioning of the blood-brain barrier
Mark R. Mizee, Gijs Kooij, Helga E. de Vries

Chapter 9: Neuroinflammation in Alzheimer's disease
Veronika M. Reinisch, Daniela L. Krause, Norbert Muller

Chapter 10: Neuroinflammation in Huntington's Disease
Roland G. W. Staal, Thomas Moeller

Chapter 11: Neuroinflammation and immune regulation in ischemic stroke: identification of new pharmacological targets
Mario Di Napoli, Craig J. Smith, Stephen J. Hopkins, Aurel Popa-Wagner, Ana Maria Buga, Mark Slevic

Part 3: Infectious Diseases
Chapter 12: HIV/NeuroAIDS
Kelly Stauch, Howard S. Fox

Chapter 13: Herpes Simplex Virus Infections Of The Central Nervous System
Richard J. Whitley

Chapter 14: Congenital Cytomegalovirus Disease
Mark R. Schleiss

Chapter 15: Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System
Kallol Dutta, Anirban Basu

Chapter 16: The biology and clinical consequence of infection with the human polyomavirus JCV
G. von Geldern, M. J. Barhams, E.O. Major

Chapter 17: Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease
Gregory Antell, Michael R. Nonnemacher, Vanessa Pirrone, Brian Wigdahl

Chapter 18: Immunopathogenesis of bacterial meningitis
Uwe Koedel, Matthias Klein, Hans-Walter Pfister

Chapter 19: Cerebral Malaria
Gregory S. Park, Chandy C. John

Part 4: Drugs of Abuse and NeuroAIDS
Chapter 20: HIV and Cocaine Interplay in HIV-associated Neurocognitive Disorders
Honghong Yao, Crstal Bethel-Brown, Shilpa Buch

Chapter 21: Methamphetamine Neurotoxicity and Neuroinflammatory Processes
Nicole A. Northrop, Bryan K. Yamamoto

Chapter 22: Drugs of Abuse and NeuroAIDS: Opiates
Thomas J. Rogers

Chapter 23: Cannabinoids
Paige S. Katz, Patricia E. Molina

Chapter 24: Alcohol and Neurodegeneration
Yuri Persidsky, Larisa Goffman, Raghava Potula

Part 5: Novel Approaches to Therapy
Chapter 25: Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes
JoEllyn M. McMillan, Howard E. Gendelman

Chapter 26: Immunomodulatory Therapeutics for Neurodegenerative Diseases
David J. Graber, William F. Hickey

Chapter 27: Therapeutic Potential Of Cannabinoids
Guy A. Cabral, Melissa Jamerson