Main description:

Neurovascular Coupling Methods brings the reader up to date with the current state-of-the-art techniques in measuring blood flow in the brain, with chapters describing different techniques or combinations of techniques, applied to specific species in either healthy or abnormal brains. Opening with a section on techniques in normal somatosensory processing, the detailed volume continues with parts covering techniques in normal visual processing, epilepsy and cerebrovascular diseases, such as ischemia, hemorrhage and spreading depression. As a collection in the popular Neuromethods series, this book contains the kind of thorough description and implementation advice that will lead to successful results in the lab.

Authoritative and practical, Neurovascular Coupling Methods serves as an ideal guide for researchers aiming to further our knowledge of these coupling mechanisms in the hopes of ultimately understanding higher order functions such as language and memory and developing novel brain mapping techniques that can be employed in humans.

Contents:

Part I: Neurovascular Coupling Techniques in Normal Somatosensory Processing

1. Simultaneous Functional Magnetic Resonance and Two Dimensional Optical Imaging Spectroscopy

Aneurin J. Kennerley, Luke Boorman, Sam Harris, and Jason Berwick

2. Neurovascular Coupling Investigated by Simultaneous Optical Coherence Tomography and Electrophysiology

Harsha Radhakrishnan, Maria Angela Franceschini, and Vivek J. Srinivasan

3. Studying Adenosine and Cerebral Blood Flow (CBF) Using Pharmacological Methods

H. Richard Winn and Kathryn Ko

4. Imaging Vasodynamics in the Awake Mouse Brain with Two-Photon Microscopy

Andy Y. Shih, Patrick J. Drew, and David Kleinfeld

Part II: Neurovascular Coupling Techniques in Normal Visual Processing

5. Neurovascular Coupling in the Deep Brain Using Confocal Fiber-Optic Endomicroscopy

Samuel Belanger, Bruno Oliveira Ferreira de Souza, Philippe Pouliot, Christian Casanova, and Frederic Lesage

6. Non-Invasive Neural Imaging and Tissue Oxygenation in the Visual System

Baowang Li and Ralph D. Freeman

7. High-Resolution Wide-Field Optical Imaging of Micro-Vascular Characteristics: From the Neocortex to the Eye

Ivo Vanzetta, Thomas Deneux, and Amiram Grinvald

8. Optical Intrinsic Signal Imaging for Elucidating Functional Structures in Higher Visual Area

Takayuki Sato and Manabu Tanifuji

Part III: Neurovascular Coupling Techniques in Epilepsy

9. Closed Cranial Window Applications in the Rat: Studies on Neurovascular Coupling Involving Pial Arterioles and the Glia Limitans

Haoliang Xu, Chanannait Paisansathan, and Dale A. Pelligrino

10. Multi-Spectral Imaging of Blood Volume, Metabolism, Oximetry, and Light Scattering

Mingrui Zhao, Hongtao Ma, Samuel Harris, and Theodore H. Schwartz

11. Physiological Basis of BOLD fMRI Decreases

Robert Kim, Fahmeed Hyder, and Hal Blumenfeld

12. Simultaneous Multi-Wavelength Optical Imaging of Neuronal and Hemodynamic Activity

Hongtao Ma, Mingrui Zhao, Samuel Harris, and Theodore H. Schwartz

13. Non-Invasive Laser-Induced Photoacoustic Tomography for Functional Imaging

Huabei Jiang

Part IV: Neurovascular Coupling Techniques in Cerebrovascular Disease: Ischemia, Hemorrhage, and Spreading Depression

14. Neurovascular Coupling in Relation to Cortical Spreading Depression

Henning Piilgaard and Martin Lauritzen

15. Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging

S.M. Shams Kazmi, Lisa M. Richards, and Andrew K. Dunn

16. Cerebral Monitoring and Surveillance Using High Resolution Functional Optical Imaging

Anthony D. Uglialoro, Douglas S. Pfeil, Tigran Gevorgyan, Harry L. Graber, Yong Xu, Sundeep Mangla, Frank C. Barone, Jenny Libien, Jean Charchaflieh, John G. Kral, Daniel C. Lee, and Randall L. Barbour