Main description:

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Contents:

Part I: Molecular Cell Signaling by NO in cancer
1. Inflammation-associated Carcinogenesis Involved Interaction Between with iNOS/NO and WNT/beta-catenin
Qiang Du and David A. Geller

2. NO and Genomic Stability
Vasily A. Yakovlev

3. Targeting Hyponitroxia in Cancer Therapy
Bryan Oronsky, Neil Oronsky, Michelle Lybeck, Gary Fanger, Jan Scicinski

4. Mechanism of NO-dependent Regulation of Invasion and Metastasis
Aideen E Ryan, Amy J Burke, Francis J Giles, Francis J Sullivan, Sharon A Glynn

5. NO Role in Protumorigenesis and Hypoxia
Lynne-Marie Postovit

Part II: S-nitrosylation and cancer
6. Impacts of S-nitrosylation in Cancer
Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and
Mark A. Brown

7. S-nitrosylation of Cancer Cells
Ali Bettaieb, Stephanie Plenchette, Catherine Paul, Veronique Laurens, Sabrina Romagny, Jean-Francois Jeannin

8. Role of S-nitrosylation in Cancer Metastasis
Sudjit Luanpitpong and Yon Rojanasakul

Part III: Modulation of anti-tumor immune responses by NO
9. NO Immunity and Cancer
Hermes J. Garban

10. Regulation of Anti-tumor Responses by NO
Peter Siesjoe

11. NO Immune Modulation and Tumor Growth
Naveena B. Janakiram and Chinthalapally V. Rao

Part IV: Therapeutics and overcoming resistance
12. Role of NO in Chemo-immune Resistance
Benjamin Bonavida

13. Emerging Role of NO-mediated Therapeutics
Cian M. McCrudden and Helen O. McCarthy
14. PDT and NO
Emilia Della Pietra and Valentina Rapozzi

15. Regulation of Cell Death by NO
Jordi Muntane, Francisco Gallardo-Chamizo, Sheila Pereira, Angela M. De los Santos, Angeles Rodriguez-Hernandez, Luis M. Marin, Jose M. Alamo, Francisco J Padillo

16. Discovery and Development of RRx-001
Jan Scicinski, Bryan Oronsky, Shoucheng Ning, Gary R Fanger, Susan J Knox, Mark Bednarski

Part V: NO Meditated Alterations in Gene Products
17. Nitric Oxide Coagulation and Cancer
Benjamin A. Derman, Hau C. Kwaan, Malak Elbatarny, Maha Othman

18. Neutrosphyngomyelinase 2
Bei Lei Sun and Bulent Mutus