Main description:

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer.

This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response.

The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

Contents:

Introduction

Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis

1. Non-coding RNAs: classification, biology and functioning

2. Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer

3. MicroRNAs and inflammation in colorectal cancer

4. Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer

5. Non-coding RNAs functioning in colorectal cancer stem cells

6. MicroRNA Methylation in Colorectal Cancer

7. Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer

Part II Non-coding RNAs: new class of biomarkers in colorectal cancer

8. Non-coding RNAs as biomarkers for colorectal cancer screening and early detection 9. Circulating non-coding RNAs as biomarkers in colorectal cancer

10. Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients

Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics

11. Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer

12. Non-coding RNAs: therapeutic strategies and delivery systems

13. MicroRNAs as therapeutic targets and colorectal cancer therapeutics

Summary

Index