Main description:

Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery.

Focus on drug delivery of phytomolecules

Act as bridge between natural product scientist and clinical doctors

Discusses mechanism of poor bioavailability of herbal molecules

Increases awareness towards phytochemical efficacy

Summarizes efficient novel delivery systems-based formulations.

It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.

Contents:

Contents

Preface ..................................................................................................................................................... vii

Editors ....................................................................................................................................................... ix

Contributors .............................................................................................................................................. xi

Section I Drug Delivery Systems

1. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects .............. 3

Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Ramesh K.Goyal, and Kamal Shah

2. Nanocarriers Systems and Their Application for the Delivery of Different

Phytoconstituents ........................................................................................................................... 9

Ebru Altuntas, Gulgun Yener, and Burcu OEzkan

3. Liposome-Based Nanocarrier System for Phytoconstituents .................................................... 45

Ngoc Thuy Trang Le, Linh Phuong Tran Pham, Diem Huong Tran Nguyen, Ngoc Hoang Le,

Tuong Vi Tran, Cuu Khoa Nguyen, and Dai Hai Nguyen

4. Phytosomes as Novel Carriers of Herbal Extracts ...................................................................... 69

Sevgi Gungoer, OEzlem Akbal-Dagistan, Evren Algin Yapar, Murat Kartal, and Yildiz OEzsoy

5. Lipid-Based Nanoparticles: SLN, NLC, and MAD .................................................................... 81

Rita Cortesi, Paolo Mariani, Markus Drechsler, and Elisabetta Esposito

Section II Application of Phytodrug Delivery

6. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application ...................... 105

Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, and Donatella Paolino

7. Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals to

Inorganic Nanomaterials ..............................................................................................................121

Aditya Arya and Jayanti Jha

8. Development of Ethosome Formulation for Topical Therapeutic Applications ..................... 137

Mansoureh Nazari Vishkaei, Mohamed B. Khadeer Ahamed, and Amin Malik Shah

Abdul Majid

9. Application of Phytodrug Delivery in Anticancer Therapy ..................................................... 157

Xiuhua Wang and Shirui Mao

Section III Phytomolecule Drug Delivery

10. Improved Silymarin Characteristics for Clinical Applications by Novel Drug

Delivery Systems ........................................................................................................................... 195

Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi

11. Silymarin-A Scintillating Phytoantioxidant: Clinical Applications and Bio-delivery

Problems ........................................................................................................................................ 223

Aditya Arya, Subhojit Paul, and Anamika Gangwar

12. Innovative Delivery Systems for Andrographolide Delivery ................................................... 241

A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, and A. J. Ribeiro

13. Polymeric Colloidal Carriers for Natural Polyphenolic Compounds ......................................261

Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, and

Rosario Pignatello

14. Drug Delivery Systems for the Controlled Delivery of Berberine ........................................... 283

Rosario Pignatello, Simona Cianciolo, and Agata K. Giuffrida

15. Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery ......................... 301

Ilaria Clemente, Ilaria Colzi, and Sara Falsini

16. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin:

Delivery, Possibilities and Challenges .........................................................................................313

Madhu Gupta, Vikas Sharma, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Kamal Shah, and Ramesh K. Goyal

Index .......................................................................................................................................................333