Main description:

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena.

Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

Contents:

Preface

Chapter 1 Nutritional epigenetics on ageing
Kyeong Chul Kim, Sang Won Choi

Chapter 2 Dietary Restriction, Dietary Design and the Epigenetics of Aging and Longevity
Craig Cooney

Chapter 3 Anti-inflammatory action of calorie restriction underlies the retardation of aging and age-related diseases
Dae Hyun Kim, Eun Kyeong Lee, Min Hi Park, Byeong Chul Kim, Ki Wung Chung, Byung Pal Yu, Hae Young Chung

Chapter 4 Hormonal influence and modulation on aging
Isao Shimokawa

Chapter 5 Epigenetic modification of gene expression by exercise
Sataro Goto, Kyojiro Kawakami, Hisashi Naito, Shizuo Katamoto, Zsolt Radak

Chapter 6 Metabolic and anti-oxidant adaptation to exercise: role of redox signaling
Li Lil Ji

Chapter 7 Sarcopenia and its intervention
Kunihiro Sakuma, Akihito Yamaguchi

Chapter 8 The role of functional foods and their bioactive components in bone health
Bahram Arjmandi, Sarah A Johnson

Chapter 9 Nutritional interventions for cardiovascular aging and age-related cardiovascular diseases
Ken Shinmura

Chapter 10 Calorie restriction mimetics: progress and potential
George Roth, Donald Ingram

Chapter 11 History of the study of calorie restriction in nonhuman primates conducted by the National Institute of Aging: the first decade
Donald Ingram, Julie A Mattison, Rafel de Cabo, George S Roth