Main description:

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.

Contents:

I. Angiogenic Diseases

Age-Related Macular Degeneration

Curtis L. Hagedorn and Ron A. Adelman

Endogenous Angiogenic Inhibitors in Diabetic Retinopathy

Jian-Xing Ma and Sarah X. Zhang

Corneal Angiogenesis

Trevor R. Carmichael

Polypoidal Choroidal Vasculopathy

Nahoko Ogata and Kanji Takahashi

Myopic Choroidal Neovascularization

Kyoko Ohno-Matsui and Takashi Tokoro

Mechanisms of the Formation and Stability of Retinal Blood Vessels

Jonathan Stone, Trent Sandercoe, and Jan Provis

Neovascular Glaucoma

James C. Tsai and M. Bruce Shields

Eales' Disease

Jyotirmay Biswas

Angiogenesis and Ocular Tumorigenesis

Nader Sheibani and Daniel M. Albert

Genetics of Ocular Vascular Disease

Jacquie Greenberg, Ari Ziskind, and Stephen P. Daiger

II. Endogenous Promoters and Inhibitors of Angiogenesis

Vascular Endothelial Growth Factor and Retinal Diseases

Sam Dahr and Karl G. Csaky

The Role of Fibroblast Growth Factors in Ocular Angiogenesis

Andreas Bikfalvi and Sophie Javerzat

Control of Neovascularization and Cell Survival in the Eye by PEDF

Joyce Tombran-Tink and Colin J. Barnstable

Thrombospondin: Guarding the Clear View

Arin Aurora and Olga V. Volpert

Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinases

Bela Anand-Apte

Integrins in Ocular Angiogenesis

Matthew R. Ritter and Martin Friedlander

Ocular Inflammation and Neovascularization

Chi-Chao Chan and Robert B. Nussenblatt

III. Therapeutics and Delivery for Angiogenic Eye Diseases

Anti-VEGF Therapies for Diseases of the Retina and Choroid

Ming Lu and Donald J. D'Amico

Anecortave Acetate: A Novel Ocular Angiostatic Agent

Stella M. Robertson, Alberta A. Davis, David C. Dahlin, and Abbot F. Clark

Gene Therapy for Neovascular Retinopathies

Brian J. Raisler, Kenneth I. Berns, and William W. Hauswirth

Noninvasive Delivery of DNA Into the Eye

John M. Nickerson, R. Keith Shuler, Jr., John B. Davies, Phyllis K. Dioguardi, Steven M. Wolchok, Vincent T. Ciavatta, Jeffrey H. Boatright, and Henry F. Edelhauser

Novel Drug Delivery Systems for Posterior Segment Ocular Disease

Heather Sheardown and W. Mark Saltzman

Index